Evidence map›Paper›PMID 31050049›Full record

ArticleMagnetic resonance in medicine2019

Using bidirectional chemical exchange for improved hyperpolarized [

David E Korenchan, Jeremy W Gordon, Sukumar Subramaniam, Renuka Sriram, Celine Baligand, Mark VanCriekinge, Robert Bok, Daniel B Vigneron, David M Wilson, Peder E Z Larson and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. New Horizons in HyperpolarizedMolecular imaging and biology · 2024
    Article
  3. Article
  4. Article
  5. Review
  6. Cardiac pH-Imaging With Hyperpolarized MRI.Frontiers in cardiovascular medicine · 2020
    Review
  7. HyperpolarizedOncotarget · 2019
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

David E KorenchanDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.ORCID 0000-0001-6152-5896
Jeremy W GordonDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Sukumar SubramaniamDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Renuka SriramDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Celine BaligandMolecular Imaging Research Center, French Alternative Energies and Atomic Energy Commission Fontenay-aux-Roses, France.
Mark VanCriekingeDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Robert BokDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Daniel B VigneronDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
David M WilsonDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Peder E Z LarsonDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
John KurhanewiczDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Robert R FlavellDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
University of California, San Francisco · USCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FR

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Daniel B Vigneron · 2011 to 2026
$19.9M
Novel Hyperpolarized MR Markers of Advanced Prostate Cancer TherapyR01CA166655 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN, VIGNERON, DANIEL B · 2012 to 2016
$3.0M
Hyperpolarized C-13 Diffusion MRI Measures of Cellular Transport and MetabolismR01EB016741 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LARSON, PEDER ERIC ZUFALL · 2014 to 2017
$2.0M
Application of hyperpolarized 13C interstitial pH imaging to risk stratification in prostate cancerR21EB026012 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FLAVELL, ROBERT RICHARD · 2018 to 2020
$503k
NCI NIH HHS R01 CA166655NIBIB NIH HHS P41 EB013598NIBIB NIH HHS R01 EB016741NIBIB NIH HHS R21 EB026012
6 · The paper itself

Abstract

purposeRapid chemical exchange can affect SNR and pH measurement accuracy for hyperpolarized pH imaging with [

methodsSimulations were performed under varying rates of bicarbonate-CO

resultsModeling of bicarbonate-CO

conclusionThe novel multi-EPI pulse sequence can boost CO

Indexed as

Hydrogen-Ion ConcentrationAlgorithmsAnimalsBicarbonatesImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiceNeoplasms, ExperimentalPhantoms, ImagingProstatic NeoplasmsSignal-To-Noise RatioBicarbonatesbicarbonatechemical exchangehyperpolarized13CMRINMR spectroscopy pH imaging

Identifiers

PMID31050049
PMCPMC6559833
OpenAlexW2943517642

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.