Evidence map›Paper›PMID 31049877›Full record

Trial reportAging clinical and experimental research2019

Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study.

Keliane Liberman, Rose Njemini, Yvette Luiking, Louis N Forti, Sjors Verlaan, Jürgen M Bauer, Robert Memelink, Kirsten Brandt, Lorenzo M Donini, Marcello Maggio and 5 more

Registry-linked trialOpen access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Aging clinical and experimental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07356440 (Effect of Consumption of Vegetable Protein-enriched Biscuits and Vitamin D Supplementation on the Progression of Sarcopenia in Elderly Subjects), which is not on this map. Cited by 41 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 5 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07356440 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Consumption of Vegetable Protein-enriched Biscuits and Vitamin D Supplementation on the Progression of Sarcopenia in Elderly Subjects

TypeinterventionalSponsorUniversity of UdineRan2025 to 2026Enrolled74ConditionsSarcopenia in Elderly, Sarcopenia, Nutritional Intervention, Microbiome AnalysisArmsVitamin D3 supplement, Protein-enriched biscuits, Control biscuit, Placebo oil
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 5 syntheses or guidelines pooled it, 78 citations in OpenAlex.

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  15. Why Osteosarcopenia Matters: Clinical and Investigative Implications.European journal of clinical investigation · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 6 countries.

Keliane LibermanFrailty in Ageing Research Group (FRIA), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090, Brussels, Belgium.
Rose NjeminiFrailty in Ageing Research Group (FRIA), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090, Brussels, Belgium.
Yvette LuikingNutricia Research, Nutricia Advanced Medical Nutrition, Utrecht, The Netherlands.
Louis N FortiFrailty in Ageing Research Group (FRIA), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090, Brussels, Belgium.
Sjors VerlaanDepartment of Internal Medicine, Section of Gerontology and Geriatrics, VU University Medical Center, Amsterdam, The Netherlands.
Jürgen M BauerCenter of Geriatric Medicine, Heidelberg University, Heidelberg, Germany.
Robert MemelinkFrailty in Ageing Research Group (FRIA), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090, Brussels, Belgium.
Kirsten BrandtHuman Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
Lorenzo M DoniniDepartment of Experimental Medicine, Section of Medical Pathophysiology, Endocrinology and Human Nutrition, "Sapienza" University of Rome, Rome, Italy.
Marcello MaggioDepartment of Medicine and Surgery, Section of Geriatrics, University of Parma, Parma, Italy.
Tony MetsFrailty in Ageing Research Group (FRIA), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090, Brussels, Belgium.
Sander L J WijersNutricia Research, Nutricia Advanced Medical Nutrition, Utrecht, The Netherlands.
Cornel SieberFriedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Tommy CederholmDepartment of Public Health and Caring Nutrition Sciences/Clinical and Metabolism, Department of Geriatric Medicine, Uppsala University Hospital, Uppsala, Sweden.
Ivan BautmansFrailty in Ageing Research Group (FRIA), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090, Brussels, Belgium. ivan.bautmans@vub.be.ORCID http://orcid.org/0000-0002-6820-9586
Vrije Universiteit Brussel · BENutricia Research (Netherlands) · NLAmsterdam UMC Location Vrije Universiteit Amsterdam · NLFriedrich-Alexander-Universität Erlangen-Nürnberg · DEHeidelberg University · DENewcastle University · GBSapienza University of Rome · ITUniversity of Parma · ITUppsala University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA chronic low-grade inflammatory profile (CLIP) is associated with sarcopenia in older adults. Protein and Vitamin (Vit)D have immune-modulatory potential, but evidence for effects of nutritional supplementation on CLIP is limited.

aimTo investigate whether 13 weeks of nutritional supplementation of VitD and leucine-enriched whey protein affected CLIP in subjects enrolled in the PROVIDE-study, as a secondary analysis.

methodsSarcopenic adults (low skeletal muscle mass) aged ≥ 65 years with mobility limitations (Short Physical Performance Battery 4-9) and a body mass index of 20-30 kg/m

resultsIL-6 and IL-1Ra serum levels showed overall increases after 13 weeks (p = 0.006 and p < 0.001, respectively). For IL-6 a significant time × treatment interaction (p = 0.046) was observed, with no significant change over time in the active group (p = 0.155) compared to control (significant increase p = 0.012). IL-8 showed an overall significant decrease (p = 0.03). The change in pre-albumin was a significant predictor for changes in IL-6 after 13 weeks.

conclusionsWe conclude that 13 weeks of nutritional supplementation with VitD and leucine-enriched whey protein may attenuate the progression of CLIP in older sarcopenic persons with mobility limitations.

Indexed as

AgedAged, 80 and overDietary SupplementsDouble-Blind MethodFemaleHumansInterleukin 1 Receptor Antagonist ProteinInterleukin-6LeucineMaleMiddle AgedMobility LimitationMuscle, SkeletalSarcopeniaVitamin DWhey ProteinsInterleukin 1 Receptor Antagonist ProteinInterleukin-6LeucineVitamin DWhey ProteinsAgedCytokinesDietary supplementsLeucineVitamin DWhey proteins

Identifiers

PMID31049877
PMCPMC6583678
OpenAlexW2943681140

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.