Evidence map›Paper›PMID 31049838›Full record

ReviewCurrent topics in behavioral neurosciences2020

Herpes Simplex Virus Type-1 Infection: Associations with Inflammation and Cognitive Aging in Relation to Schizophrenia.

Vishwajit L Nimgaonkar, Triptish Bhatia, Abdelaziz Mansour, Maribeth A Wesesky, Smita Deshpande

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current topics in behavioral neurosciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vishwajit L NimgaonkarDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. nimga@pitt.edu.
Triptish BhatiaTraining Program for Psychiatric Genetics in India, Post-graduate Institute for Medical Education and Research, Dr Ram Manohar Lohia Hospital, Delhi, India.
Abdelaziz MansourDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Maribeth A WeseskyDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Smita DeshpandePost-graduate Institute for Medical Education and Research, Dr Ram Manohar Lohia Hospital, New Delhi, India.

Funding

Psychiatric research infrastructure for intervention and implementation in India – TEAMSD43TW009114 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Smita N Deshpande, Mary Elizabeth Hawk · 2014 to 2026
$3.2M
FIC NIH HHS D43 TW009114
6 · The paper itself

Abstract

Most persons experience cognitive decline as they grow older. The term "cognitive aging," coined to describe milder varieties of cognitive decline, is likely to be due to multiple causes. Persistent or repeated infections of the central nervous system (whether subclinical or diagnosable) can cause damage to neurons directly or indirectly through inflammation resulting in incremental neuronal damage, thus eroding cognitive reserve. This possibility has not been considered widely. We evaluated the data linking persistent infection with herpes simplex virus type 1 (HSV-1) and cognitive aging by applying the Bradford Hill criteria. Despite inherent problems in establishing causal relations for chronic disorders, our analyses suggest plausible links. These studies are pertinent for patients with schizophrenia, who are particularly vulnerable due to disorder-related cognitive impairment. Further investigations are warranted to test a causal hypothesis, particularly prospective studies and intervention studies.

Indexed as

Cognition DisordersCognitive AgingHerpes SimplexHerpesvirus 1, HumanSchizophreniaHumansInflammationProspective StudiesBradford Hill criteriaCausalityCognitive agingHerpes virusHSV-1Schizophrenia

Identifiers

PMID31049838
PMCPMC12378336

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.