Evidence map›Paper›PMID 31049819›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2020

Survival outcomes in patients aged 75 years and over with peritoneal colorectal carcinomatosis after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC): multicenter study of the Spanish Group of Peritoneal Cancer Surgery (GECOP).

P A Cascales-Campos, V López-López, J Torres-Melero, A Arjona, F C Muñoz-Casares, P Barrios, R Morales, F Pereira, P Bretcha-Boix, L González-Bayón and 2 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Elderly Rectal Cancer: An Updated Review.Current oncology reports · 2024
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

P A Cascales-CamposHospital Clínico, Universitario Virgen De La Arrixaca, Carretera Madrid-Cartagena S/N, El Palmar, CP: 30120, Murcia, Spain. cascalescirugia@gmail.com.ORCID http://orcid.org/0000-0001-6703-6372
V López-LópezHospital Clínico, Universitario Virgen De La Arrixaca, Carretera Madrid-Cartagena S/N, El Palmar, CP: 30120, Murcia, Spain.
J Torres-MeleroHospital Universitario De Torrecárdenas, Almería, Andalucia, Spain.
A ArjonaHospital Universitario Reina Sofía, Córdoba, Andalucia, Spain.
F C Muñoz-CasaresHospital Universitario Reina Sofía, Córdoba, Andalucia, Spain.
P BarriosHospital De Sant Joan De Espi Moises Broggi, Sant Joan De Espi, Cataluña, Spain.
R MoralesHospital Universitario Son Espases, Palma de Mayorca, Islas Baleares, Spain.
F PereiraHospital Universitario De Fuenlabrada, Madrid, Spain.
P Bretcha-BoixHospital Quirón de Torrevieja, Alicante, Comunidad Valenciana, Spain.
L González-BayónHospital General Universitario Gregorio Marañón, Madrid, Spain.
S González-MorenoMD Anderson Cancer Center, Madrid, Spain.
J GilHospital Clínico, Universitario Virgen De La Arrixaca, Carretera Madrid-Cartagena S/N, El Palmar, CP: 30120, Murcia, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe attitude toward cytoreductive surgery with HIPEC in peritoneal carcinomatosis from colorectal cancer is unclear. The aim of this study is to report the perioperative outcomes after cytoreductive surgery with HIPEC in patients ≥ 75 years.

methodsThis retrospective multicenter study collected the data the Spanish Group of Peritoneal Cancer Surgery. Thirty-six patients with peritoneal carcinomatosis from colorectal cancer met the selection criteria for the study. Morbidity, mortality, disease-free and overall survival were analyzed.

resultsMorbidity (grade III-IV) was 17% and 2 patients died of complications related to the procedure (5.4%). Median disease-free survival (DFS) was 16 months. DFS at 1 and 3 years was 81% and 42%, respectively. Overall survival at 1 and 3 years was 96% and 75%. In the univariate analysis, preoperative comorbidities (p = 0.01), liver metastases (p = 0.02), blood transfusion (p = 0.001) and postoperative complications (p = 0.001); and in the multivariate analysis, perioperative blood transfusion (OR 2.56, 95% CI 1.95-6.24, p = 0.03) and postoperative complications (OR 3.25, 95% CI 2.35-7.56, p = 0.02) were associated with a lower overall survival.

conclusionsAge is not an absolute contraindication to perform cytoreduction surgery with HIPEC in highly selected elderly patients with colorectal peritoneal carcinomatosis.

Indexed as

AgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsChemotherapy, Cancer, Regional PerfusionColorectal NeoplasmsCombined Modality TherapyCytoreduction Surgical ProceduresFemaleFollow-Up StudiesHumansHyperthermia, InducedMalePeritoneal NeoplasmsPrognosisRetrospective StudiesSpainColorectal carcinomatosisElderlyHIPECMorbiditySurvival

Identifiers

PMID31049819

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.