ReviewDrugs & aging2019
Statins for Primary Prevention in Those Aged 70 Years and Older: A Critical Review of Recent Cholesterol Guidelines.
Review in Drugs & aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Deprescribing statins for adults 65 years of age and older: Evidence-based clinical practice guideline.Canadian family physician Medecin de famille canadien · 2026Guideline
- Association between Statins Prescribed for Primary and Secondary Prevention and Major Adverse Cardiac Events among Older Adults with Frailty: A Systematic Review.Drugs & aging · 2020 · on this mapPooled it
- The Safety and Tolerability of Statin Therapy in Primary Prevention in Older Adults: A Systematic Review and Meta-analysis.Drugs & aging · 2020 · on this mapPooled it
- Ezetimibe alone for over 75 years old as a primary prevention to decrease cardiovascular events.Annals of medicine · 2026Article
- Assessing the impact of aggressive versus intermediate LDL-C goal achievement in Asian adults: a retrospective cohort study using national health insurance service-senior cohort.Lipids in health and disease · 2025Article
- Trends in statin prescription among osteoporosis patients: A retrospective cohort study using UK primary care data.PLOS global public health · 2025Article
- Many studies, but little certainty about the effects of statin discontinuation on outcomes.Journal of the American Geriatrics Society · 2024Article
- Treating Hypercholesterolemia in Older Adults for Primary Prevention of Cardiovascular Events.Drugs & aging · 2024Review
- Optimizing lipid control in Taiwanese diabetic patients: A collaborative consensus by the Diabetes Association of the Republic of China (Taiwan) and the Taiwanese Association of Diabetes Educators.Journal of diabetes investigation · 2024Article
- The role of statin therapy in older adults: best practices and unmet challenges.Expert review of cardiovascular therapy · 2024Review
- Dyslipidaemia in elderly and stroke patients.Indian heart journal · 2024Review
- Optimizing Medications with the Geriatrics 5Ms: An Age-Friendly Approach.Drugs & aging · 2023Article
- Impact of medication reviews on drug-related problems (DRPs) in older patients living in nursing homes in West Occitania.Fundamental & clinical pharmacology · 2023Article
- Statin therapy in multimorbid older patients with polypharmacy- a cross-sectional analysis of the Swiss OPERAM trial population.Frontiers in cardiovascular medicine · 2023Article
- Association between willingness to deprescribe and health outcome priorities among U.S. older adults: Results of a national survey.Journal of the American Geriatrics Society · 2022Article
- Current status of low-density lipoprotein cholesterol for primary prevention of coronary artery disease in late-stage elderly persons with type 2 diabetes mellitus: A retrospective, single-center study.Journal of diabetes investigation · 2022Article
- Association between low-density lipoprotein cholesterol and cardiovascular mortality in statin non-users: a prospective cohort study in 14.9 million Korean adults.International journal of epidemiology · 2022Article
- Protective effects of statins on COVID-19 risk, severity and fatal outcome: a nationwide Swedish cohort study.Scientific reports · 2022Article
- An Ounce of Prevention, a Pound of Complications: A Case of Statin-Induced Necrotizing Myopathy in a Frail Elderly Patient.Geriatrics (Basel, Switzerland) · 2022Article
- Statin Discontinuation and Cardiovascular Events Among Older People in Denmark.JAMA network open · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The risk of atherosclerotic cardiovascular disease rises with age and remains the leading cause of death in older adults. Evidence for the use of statins for primary prevention in older adults is limited, despite the possibility that this population may derive significant clinical benefit given its increased cardiovascular risk. Until publication of the 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the Management of Blood Cholesterol, and the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease, guidelines for statin prescription in older adults remained unchanged despite new evidence of possible benefit in older adults. In this review, we present key updates in the 2018 and 2019 guidelines and the evidence informing these updates. We compare the discordant recommendations of the seven major North American and European guidelines on cholesterol management released in the past 5 years and highlight gaps in the literature regarding primary prevention of cardiovascular disease in older adults. As most cardiovascular events in older adults are nonfatal, we ask how clinicians should weigh the risks and benefits of continuing a statin for primary prevention in older adults. We also reframe the concept of deprescribing of statins in the older population, using the Geriatrics 5Ms framework: Mind, Mobility, Medications, Multi-complexity, and what Matters Most to older adults. A recent call from the National Institute on Aging for a statin trial focusing on older adults extends from similar concerns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.