Evidence map›Paper›PMID 31049792›Full record

SynthesisTechniques in coloproctology2019

The clinical efficacy of stem cell therapy for complex perianal fistulas: a meta-analysis.

S Choi, B G Jeon, G Chae, S-J Lee

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Techniques in coloproctology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

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  14. Mesenchymal stem cells in perianal Crohn's disease.Techniques in coloproctology · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

S ChoiDepartment of Surgery, Kangwon National University School of Medicine, Kangwon National University Hospital, Chuncheon, South Korea.
B G JeonDepartment of Surgery, Daejin Medical Center, Bundang Jesaeng General Hospital, Sungnam-Si, South Korea.
G ChaeDepartment of Surgery, Kangwon National University School of Medicine, Kangwon National University Hospital, Chuncheon, South Korea.
S-J LeeDepartment of Surgery, Chungbuk National University College of Medicine, Chungbuk National University Hospital, 1 Chungdae-ro, Seowon-gu, Cheongju, 28644, South Korea. colon@chungbuk.ac.kr.ORCID http://orcid.org/0000-0001-7883-5858
Kangwon National University Hospital · KRBundang Jesaeng Hospital · KRChungbuk National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTreatment of complex anal fistulas remains difficult. However, treatment with stem cells has had an encouraging success rate when applied to complex perianal fistulas. We systematically reviewed the current evidence through meta-analysis.

methodsWe performed an electronic literature search on PubMed, Embase, and the Cochrane Library and identified studies (published between January 1946 and August 2017) that used stem cells to treat patients with complex perianal fistula. Each paper was evaluated for treatment success rate, target patients, types of stem cells used, number of cells used, and criteria for complete healing. Potential publication bias was assessed via visual inspection of a funnel plot and Orwin's fail-safe N. Out of 171 papers, 16 were included in the meta-analysis.

resultsThe overall healing rate of stem cell injection therapy for patients with complex perianal fistulas was 62.8% (95% CI 53.5-71.2, I

conclusionsStem cell therapy is a good treatment option for complex perianal fistulas, which cannot be healed by conventional operative procedures. However, further research for additional supportive evidence, such as a large-scale randomized controlled trial, is required.

Indexed as

Stem Cell TransplantationCutaneous FistulaHumansRectal FistulaTreatment OutcomeAdipose-derived stem cellsAnorectal fistulaComplexMeta-analysis

Identifiers

PMID31049792
OpenAlexW2943153012

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.