ArticleBiomechanics and modeling in mechanobiology2019
A micromechanical muscle model for determining the impact of motor unit fiber clustering on force transmission in aging skeletal muscle.
Article in Biomechanics and modeling in mechanobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Article
- Modelling motor units in 3D: influence on muscle contraction and joint force via a proof of concept simulation.Biomechanics and modeling in mechanobiology · 2023Article
- Modelling intra-muscular contraction dynamics using in silico to in vivo domain translation.Biomedical engineering online · 2022Article
- Increase of resting muscle stiffness, a less considered component of age-related skeletal muscle impairment.European journal of translational myology · 2020Article
- Alterations of Extracellular Matrix Mechanical Properties Contribute to Age-Related Functional Impairment of Human Skeletal Muscles.International journal of molecular sciences · 2020Article
- Investigating Passive Muscle Mechanics With Biaxial Stretch.Frontiers in physiology · 2020Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
This study used a micromechanical finite element muscle model to investigate the effects of the redistribution of spatial activation patterns in young and old muscle. The geometry consisted of a bundle of 19 active muscle fibers encased in endomysium sheets, surrounded by passive tissue to model a fascicle. Force was induced by activating combinations of the 19 active muscle fibers. The spacial clustering of muscle fibers modeled in this study showed unbalanced strains suggesting tissue damage at higher strain levels may occur during higher levels of activation and/or during dynamic conditions. These patterns of motor unit remodeling are one of the consequences of motor unit loss and reinnervation associated with aging. The results did not reveal evident quantitative changes in force transmission between old and young adults, but the patterns of stress and strain distribution were affected, suggesting an uneven distribution of the forces may occur within the fascicle that could provide a mechanism for muscle injury in older muscle.
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