Evidence map›Paper›PMID 31049759›Full record

ReviewInternational journal of clinical oncology2019

Immune check-point in endometrial cancer.

Francesca De Felice, Claudia Marchetti, Vincenzo Tombolini, P Benedetti Panici

Abstract readReview
PubMed Publisher
In one paragraph

Review in International journal of clinical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

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  20. The Hallmarks of Flavonoids in Cancer.Molecules (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Francesca De FeliceDepartment of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Viale Regina Elena 326, 00161, Rome, Italy. fradefelice@hotmail.it.ORCID http://orcid.org/0000-0002-5119-8358
Claudia MarchettiDivision of Gynecologic Oncology, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy.
Vincenzo TomboliniDepartment of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Viale Regina Elena 326, 00161, Rome, Italy.
P Benedetti PaniciDepartment of Gynecological, Obstetrical Sciences and Urological Sciences "Sapienza" University of Rome, Rome, Italy.
Policlinico Umberto I · ITAgostino Gemelli University Polyclinic · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndometrial cancer (EC) is one of the most frequent tumors in women. Despite recent advances in treatment approaches, the prognosis in advanced, recurrent, or metastatic disease remains poor. The aim was to provide the clinician with an update, the current status, and the new developments in the management of EC. Based on the new EC molecular classification, we focused on the impact of immune check-point inhibitors.

methodsPivotal trials, published literature, and conference proceedings were reviewed. PubMed and Scopus databases were searched to select English-language articles.

resultsImmune check-point inhibitors are the subject of ongoing studies and their benefit seems to be related to microsatellite instability (MSI) status.

conclusionsImmune check-point inhibitors should be considered a promising treatment option to better personalize therapeutic strategies in EC.

Indexed as

Microsatellite InstabilityAntineoplastic Agents, ImmunologicalCell Cycle CheckpointsEndometrial NeoplasmsFemaleHumansImmunotherapyPrognosisAntineoplastic Agents, ImmunologicalEndometrial cancerImmune check-pointImmunotherapyMicrosatellite instabilityMismatch repairSurvival

Identifiers

PMID31049759
OpenAlexW2943457748

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.