ArticleCancer causes & control : CCC2019
The Mind-Body Study: study design and reproducibility and interrelationships of psychosocial factors in the Nurses' Health Study II.
Article in Cancer causes & control : CCC, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations of depression status with plasma levels of candidate lipid and amino acid metabolites: a meta-analysis of individual data from three independent samples of US postmenopausal women.Molecular psychiatry · 2021Pooled it
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- Empirical dietary index for lower urate concentrations and risk of gout: evidence from cohort studies.The American journal of clinical nutrition · 2025Article
- Group-wise normalization in differential abundance analysis of microbiome samples.BMC bioinformatics · 2025Article
- Amino acid intake, plasma metabolites, and incident type 2 diabetes risk: a systematic approach in prospective cohort studies.Nutrition journal · 2025Observational
- Association between sedentary behavior, depressive symptoms, and the risk of all-cause and cause-specific mortality among U.S. cancer survivors.BMC cancer · 2025Article
- Persistent PTSD symptoms are associated with plasma metabolic alterations relevant to long-term health: A metabolome-wide investigation in women.Psychological medicine · 2025Article
- Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts.Nature microbiology · 2024Article
- An Empirical Dietary Pattern Associated With the Gut Microbial Features in Relation to Colorectal Cancer Risk.Gastroenterology · 2024Article
- F. prausnitzii potentially modulates the association between citrus intake and depression.Microbiome · 2024Article
- Persistent PTSD symptoms are associated with plasma metabolic alterations relevant to long-term health: A metabolome-wide investigation in women.medRxiv : the preprint server for health sciences · 2024Article
- Pet Attachment and Anxiety and Depression in Middle-Aged and Older Women.JAMA network open · 2024Article
- Association of Probable Post-Traumatic Stress Disorder with Dietary Pattern and Gut Microbiome in a Cohort of Women.Nature. Mental health · 2023Article
- Gut feelings: associations of emotions and emotion regulation with the gut microbiome in women.Psychological medicine · 2023Article
- Posttraumatic Stress Disorder, Depression, and Accelerated Aging: Leukocyte Telomere Length in the Nurses' Health Study II.Biological psychiatry global open science · 2023Article
- The gut microbiome modifies the associations of short- and long-term physical activity with body weight changes.Microbiome · 2023Article
- Health-related quality of life and psychological indicators of thriving 15-19 years after heart or lung transplantation.Clinical transplantation · 2022Article
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8 authors.
Funding
Abstract
purposeAssociations between psychosocial factors and biomarkers are increasingly investigated in studies of cancer incidence and mortality. Documenting optimal data/biospecimen collection protocols and scale properties are fundamental for elucidating the impact of psychosocial factors on biologic systems and ultimately cancer development/progression.
methodsBetween 2013 and 2014, 233 Nurses' Health Study II women (mean age: 60.6) participated in the Mind-Body Study. Participants completed a detailed online psychosocial assessment and provided hair, toenail, timed saliva over 1 day, urine and fasting blood twice, 1 year apart. Additionally, two separate microbiome collections for stool and saliva were conducted between the psychosocial assessments. We assessed correlations between various psychosocial measures and evaluated their 1-year reproducibility using intraclass correlations (ICC).
resultsCompliance with the protocols was high among participants. Psychosocial measures showed moderate-to-high reproducibility over 1 year (ICCs = 0.51-0.81). There was clear clustering of psychosocial factors according to whether they were querying positive (e.g., optimism, mastery, mindfulness) or negative (e.g., anxiety, depression, discrimination) emotion-related or social constructs.
conclusionResults suggest feasibility for self-administered collection of various biospecimens and moderate-to-high reproducibility of psychosocial factors. The Mind-Body Study provides a unique resource for assessing inter-relationships between psychosocial factors and biological processes linked with long-term health outcomes, including carcinogenesis.
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