ArticleClinical and experimental nephrology2019
A quantitative approach to intravenous fluid therapy in the syndrome of inappropriate antidiuretic hormone secretion.
Article in Clinical and experimental nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 12 citations in OpenAlex.
- Hyponatraemic seizure in a healthy adult due to stress-associated non-osmotic vasopressin-mediated antidiuresis on a low-solute background: a case report.International journal of emergency medicine · 2026Article
- Urine sodium levels post-saline infusion in differentiating non-edematous hyponatremia.Scientific reports · 2025Article
- Examining the significance of arginine vasopressin release to elucidate the often multifactorial etiology of hypotonic hyponatremia: A novel criterion.Physiological reports · 2024Article
- Osmotic demyelination syndrome: clinical and neuroimaging characteristics in a series of 8 cases.Quantitative imaging in medicine and surgery · 2023Article
- Osmotic demyelination syndrome and thoughts on its prevention.Journal of nephrology · 2022Article
- A novel clinical nomogram for the evaluation of disorders of plasma osmolality.Clinical kidney journal · 2021Article
- Article
- Edelman Revisited: Concepts, Achievements, and Challenges.Frontiers in medicine · 2021Review
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundA wide range of interesting mathematical models has been derived to predict the effect of intravenous fluid therapy on the serum sodium concentration (most notably the Adrogué-Madias equation), but unfortunately, these models cannot be applied to patients with disorders characterized by aberrant antidiuretic hormone (ADH) release, such as the syndrome of inappropriate ADH secretion (SIADH). The use of intravenous fluids in these patients should prompt caution, as the inability of the kidneys to properly dilute the urine can easily result in deterioration of hyponatremia.
methodsIn this report, a transparent and clinically applicable equation is derived that can be used to calculate the estimated effect of different types and volumes of crystalloid infusate on the serum sodium concentration in SIADH patients. As a "proof of concept", we discuss five SIADH patient cases from our clinic. Alternatively, our mathematical model can be used to determine the infusate volume that is required to produce a certain desired change in the serum sodium concentration in SIADH patients.
conclusionThe presented model facilitates rational intravenous fluid therapy in SIADH patients, and provides a valuable addition to existing prediction models.
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