ArticlePediatric nephrology (Berlin, Germany)2019
Depression and neurocognitive dysfunction in pediatric and young adult chronic kidney disease.
Article in Pediatric nephrology (Berlin, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Emotional, behavioural and adaptive function in children with chronic kidney disease: the Kids with CKD (KCAD) study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Association of problems, coping styles, and preferred online activity with depression, anxiety, and other psychological disorders in Turkish adolescents diagnosed with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2024Article
- Mental health and social-emotional functioning in children and adolescents with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2024Review
- Holistic care and symptom management for pediatric kidney transplant recipients.Pediatric nephrology (Berlin, Germany) · 2024Article
- Mental Health and Quality of Life in Chronic Kidney Disease Patients with Mild-to-Moderate Depression: A Retrospective Cohort Study of Mindfulness-Based Stress Reduction Therapy.Actas espanolas de psiquiatria · 2024Article
- Taking care of myself in a different and broken world: self-care practices of adolescents on dialysis.International journal of qualitative studies on health and well-being · 2023Article
- Depression and health-related quality of life in adolescents and young adults with childhood-onset end-stage kidney disease: a multicenter study in Japan.Clinical and experimental nephrology · 2023Article
- Associations of body mass index (BMI) and BMI change with progression of chronic kidney disease in children.Pediatric nephrology (Berlin, Germany) · 2023Article
- Psychiatric Diagnoses in Children With CKD Compared to the General Population.Kidney medicine · 2022Article
- Prevalence of cognitive dysfunction and its risk factors in children with chronic kidney disease in a developing country.Pediatric nephrology (Berlin, Germany) · 2022Article
- The Burden of Mental Health Conditions in Children With CKD.Kidney medicine · 2022Article
- Safeguarding children and young people requiring kidney replacement therapy: challenges and potential opportunities.Pediatric nephrology (Berlin, Germany) · 2022Article
- Factors Affecting Neurocognitive Function in Children with Chronic Kidney Disease: A Systematic Review.International journal of nephrology and renovascular disease · 2022Review
- Review
- The Similarities and Differences Between Glomerular vs. Non-glomerular Diagnoses on Intelligence and Executive Functions in Pediatric Chronic Kidney Disease: A Brief Report.Frontiers in neurology · 2021Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDepression affects 7-35% of children with chronic kidney disease (CKD), and in adults with CKD, the presence of depression links to poorer medical outcomes, social functioning difficulties, and neurocognitive impairments. The relationship between depression and neurocognitive function in youth with CKD is unclear. We sought to identify factors associated with depression in youth with CKD and to determine whether depression affects neurocognitive performance.
methodsWe conducted cross-sectional analyses in 71 CKD and 64 control participants aged 8 to 25 years who completed depression inventories and neurocognitive assessments as part of the Neurocognitive Assessment and Magnetic Resonance Imaging Analysis of Children and Young Adults with CKD Study. In the CKD group, multivariable logistic regression analysis determined associations between clinical and demographic factors and depression. In the full study cohort, multivariable linear regression analyses, including an interaction term between CKD status and depression evaluated the effect of depression on 11 neurocognitive outcome domains.
resultsObesity significantly associated with depression in the CKD group (OR 10.25, P = 0.01). In adjusted analyses, depressed youth with CKD scored worse than non-depressed CKD participants by 0.6-1.0 standard deviations in 5 neurocognitive domains: attention, visual memory, visual-spatial, visual working memory, and problem solving.
conclusionsCKD youth with obesity are more likely to be depressed, and those who are depressed exhibit worse neurocognitive performance. Depression may represent a therapeutic target to improve neurocognitive performance in youth with CKD.
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