Evidence map›Paper›PMID 31049718›Full record

Observational studyPediatric nephrology (Berlin, Germany)2019

Estimating glomerular filtration rate in youth with obesity and type 2 diabetes: the iCARE study equation.

A B Dart, J McGavock, A Sharma, D Chateau, G J Schwartz, T Blydt-Hansen

Abstract readObservational StudyValidation Study
PubMed Publisher
In one paragraph

Observational study in Pediatric nephrology (Berlin, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Article
  4. Article
  5. Glomerular hyperfiltration: part 2-clinical significance in children.Pediatric nephrology (Berlin, Germany) · 2023
    Review
  6. Observational
  7. Article
  8. Article
  9. [Current clinical application of glomerular filtration rate assessment methods in pediatric populations].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

A B DartDepartment of Pediatrics and Child Health, Section of Nephrology, Children's Hospital Research Institute of Manitoba, Diabetes Research Envisioned and Accomplished in Manitoba Research Team, University of Manitoba, FE009 - 840 Sherbrook Street, Winnipeg, MB, R3A 1S1, Canada. adart@hsc.mb.ca.ORCID 0000-0002-4718-9408
J McGavockDepartment of Pediatrics and Child Health, University of Manitoba, FE009 - 840 Sherbrook Street, Winnipeg, MB, R3A 1S1, Canada.
A SharmaDepartment of Pediatrics and Child Health, University of Manitoba, FE009 - 840 Sherbrook Street, Winnipeg, MB, R3A 1S1, Canada.
D ChateauDepartment of Community Health Sciences, University of Manitoba, Winnipeg, Canada.
G J SchwartzUniversity of Rochester Medical Center, Rochester, NY, USA.
T Blydt-HansenDepartment of Pediatrics, University of British Columbia, Vancouver, Canada.
University of Manitoba · CAChildren's Hospital Research Institute of Manitoba · CAUniversity of British Columbia · CAUniversity of Rochester Medical Center · US

Funding

Central Biochemistry Laboratory of the CKID ConsortiumU24DK082194 · NIDDK · UNIVERSITY OF ROCHESTER · PI SCHWARTZ, GEORGE J · 2018 to 2022
$1.7M
NIDDK NIH HHS U24 DK082194
6 · The paper itself

Abstract

backgroundThe validity of pediatric estimated glomerular filtration rate equations (eGFRs) in early stages of CKD including hyperfiltration is unknown. The purpose of this study was to develop an eGFR equation for adolescents with obesity and type 2 diabetes (T2D).

methodseGFRs were developed from iohexol-derived GFRs (iGFRs) in 26 overweight/obese (BMI > 85th percentile) youth and 100 with T2D from the iCARE (Improving renal Complications in Adolescents with T2D through REsearch) cohort. Twenty percent of the cohort was withheld as a validation dataset. Linear regression analyses were used to develop the best formula based on body size, sex, creatinine, urea, ± cystatin C. Comparable validity of commonly used eGFR equations was assessed.

resultsMean age 15.4 + 2.4 years, BMI Z-score 2.5 + 1.2, 61% female, and mean iGFR 129.0 + 27.7 ml/min/ 1.73 m

conclusionsThe iCARE equation provides a more accurate creatinine-based eGFR in obese youth with and without T2D. Further studies are warranted to evaluate within-subject variability and applicability to lower GFRs and other populations.

Indexed as

Models, BiologicalAdolescentAge of OnsetCreatinineCross-Sectional StudiesCystatin CDatasets as TopicDiabetes Mellitus, Type 2FemaleGlomerular Filtration RateHumansIohexolMaleObesityRenal EliminationRenal Insufficiency, ChronicCreatinineCystatin CIohexolUreaeGFRHyperfiltrationObeseType 2 diabetesYouth

Identifiers

PMID31049718
OpenAlexW2943711223

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.