Evidence map›Paper›PMID 31049712›Full record

ArticleMikrochimica acta2019

Spectrophotometric determination of the activity of alkaline phosphatase and detection of its inhibitors by exploiting the pyrophosphate-accelerated oxidase-like activity of nanoceria.

Pengjuan Ni, Junfeng Xie, Chuanxia Chen, Yuanyuan Jiang, Zhenlu Zhao, Yan Zhang, Yizhong Lu, Jinghua Yu

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 20 citations in OpenAlex.

  1. Antioxidant potential of nanomaterials.Turkish journal of biology = Turk biyoloji dergisi · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Pengjuan NiSchool of Materials Science and Engineering, University of Jinan, Jinan, 250022, China. mse_nipj@ujn.edu.cn.
Junfeng XieCollege of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes (Ministry of Eduction), Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in University of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan, 250014, China.
Chuanxia ChenSchool of Materials Science and Engineering, University of Jinan, Jinan, 250022, China.
Yuanyuan JiangSchool of Materials Science and Engineering, University of Jinan, Jinan, 250022, China.
Zhenlu ZhaoSchool of Materials Science and Engineering, University of Jinan, Jinan, 250022, China.
Yan ZhangSchool of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, China.
Yizhong LuSchool of Materials Science and Engineering, University of Jinan, Jinan, 250022, China. mse_luyz@ujn.edu.cn.ORCID 0000-0002-0914-2780
Jinghua YuSchool of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, China. ujn.yujh@gmail.com.
University of Jinan · CNShandong Normal University · CN

Funding

National Natural Science Foundation of China 21705056Natural Science Foundation of Shandong Province ZR2017MB022, ZR2018BB057, ZR2017PB009Taishan Scholar Project of Shandong Province ts201712048the Young Taishan Scholars Program of Shandong Province tsqn201812080
6 · The paper itself

Abstract

The oxidase-like activity of nanoceria is low. This limits its practical applications. It is demonstrated here that pyrophosphate ion (PPi) can improve the oxidase-like activity of nanoceria. Specifically, nanoceria catalyzes the oxidation of colorless 3,3',5,5'-tetramethylbenzidine (TMB) to give a blue product (oxTMB) with an absorption peak at 645 nm in the presence of PPi. If, however, alkaline phosphatase (ALP) is present, it will hydrolyze PPi, and this results in a decreased oxidase-like activity of nanoceria. Hence, less blue oxTMB willl be formed. On the other hand, if the ALP inhibitor Na

Indexed as

Alkaline PhosphataseBenzidinesCatalysisCeriumDiphosphatesEnzyme InhibitorsHumansHydrolysisLimit of DetectionOxidation-ReductionOxidoreductasesSpectrophotometryVanadates3,3',5,5'-tetramethylbenzidineAlkaline PhosphataseBenzidinesceric oxideCeriumDiphosphatesEnzyme InhibitorsOxidoreductasesVanadates3,3′,5,5′-TetramethylbenzidineCerium oxide nanoparticlesInhibitorNanozymesOxidase mimeticsSodium vanadate

Identifiers

PMID31049712
OpenAlexW2943220672

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.