ArticlePediatric radiology2019
Magnetic resonance imaging T1 relaxation times for the liver, pancreas and spleen in healthy children at 1.5 and 3 tesla.
Article in Pediatric radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Cross-Vendor Validation of Proton Density Fat Fraction and TJournal of magnetic resonance imaging : JMRI · 2026Article
- Pharmacokinetic Modeling of Hepatospecific MRI Contrast Agent Flux in Large Animal Models by Dynamic Contrast-Enhanced MRI.Molecular imaging and biology · 2026Article
- Pharmacokinetic modeling of hepatospecific MRI contrast agent flux in large animal models by dynamic contrast-enhanced MRI.Research square · 2026Article
- Automated quantification of T1 and T2 relaxation times in liver mpMRI using deep learning: a sequence-adaptive approach.European radiology experimental · 2025Article
- T1 Mapping of the Abdomen, From theAJR. American journal of roentgenology · 2025Review
- Standardized pancreatic MRI-T1 measurement methods: comparison between manual measurement and a semi-automated pipeline with automatic quality control.The British journal of radiology · 2025Article
- Simultaneous Multiparameter Mapping of the Liver in a Single Breath-Hold or Respiratory-Triggered Acquisition Using Multi-Inversion Spin and Gradient Echo MRI.Journal of magnetic resonance imaging : JMRI · 2025Article
- Liver T1 mapping in Fontan patients and patients with biventricular congenital heart disease - insights into the effects of venous congestions on diffuse liver disease.The international journal of cardiovascular imaging · 2025Article
- Magnetic resonance imaging T1 mapping of the liver, pancreas and spleen in children.Abdominal radiology (New York) · 2024Article
- Liver T1 and T2 mapping in a large cohort of healthy subjects: normal ranges and correlation with age and sex.Magma (New York, N.Y.) · 2024Article
- T1 mapping in evaluation of clinicopathologic factors for rectal adenocarcinoma.Abdominal radiology (New York) · 2024Article
- T1 mapping of the myocardium and liver in the single ventricle population.Pediatric radiology · 2023Article
- Signal intensity patterns in health and disease: basics of abdominal magnetic resonance imaging in children.Pediatric radiology · 2022Review
- Survey of water proton longitudinal relaxation in liver in vivo.Magma (New York, N.Y.) · 2021Review
- Dual flip-angle IR-FLASH with spin history mapping for B1+ corrected T1 mapping: Application to T1 cardiovascular magnetic resonance multitasking.Magnetic resonance in medicine · 2021Article
- Current State of Imaging of Pediatric Pancreatitis:AJR. American journal of roentgenology · 2021Review
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- Validation and feasibility of liver T1 mapping using free breathing MOLLI sequence in children and young adults.Scientific reports · 2020Article
- Validation of threshold values for pancreas thickness and T1-weighted signal intensity ratio in the pediatric pancreas.Pediatric radiology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundT1 relaxation time is a potential magnetic resonance imaging (MRI) biomarker for fibrosis and inflammation of the solid abdominal organs. However, normal T1 relaxation times of the solid abdominal organs have not been defined for children.
objectiveThe purpose of this study was to measure T1 relaxation times of the liver, pancreas and spleen in healthy children. MATERIALS AND
methodsThis was an institutional review board-approved study of a convenience sample of prospectively recruited, healthy children ages 7 to 17 years undergoing research abdominal MRI (1.5 or 3 T) as part of a larger research study between February 2018 and October 2018. For the current study, T1 mapping was performed with a Modified Look-Locker sequence covering the upper abdomen. A single reviewer placed freehand regions of interest on the T1 parametric maps in the liver, pancreas and spleen, inclusive of as much parenchyma as possible. Student's t-tests and linear regression were used to compare T1 values by age and gender.
resultsThirty-two participants were included (16 female:16 male; mean age: 12.2±3.1 years; n=16 at 1.5 T). Median T1 relaxation times (ms) per organ were liver: 581±64 (1.5 T), 783±88 (3 T); pancreas: 576±55 (1.5 T), 730±30 (3 T), and spleen: 1,172±71 (1.5 T), 1,356±87 (3 T). T1 values were not statistically significantly different between males and females. At both 1.5 and 3 T field strengths, linear regression showed no significant association between age and T1 values for the liver, pancreas and spleen.
conclusionWe report normal T1 relaxation times for the liver, pancreas and spleen at 1.5 and 3 T in a cohort of healthy children.
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