Evidence map›Paper›PMID 31049402›Full record

ArticleScience advances2019

Entropic effects enable life at extreme temperatures.

Young Hun Kim, Geoffray Leriche, Karthik Diraviyam, Takaoki Koyanagi, Kaifu Gao, David Onofrei, Joseph Patterson, Anirvan Guha, Nathan Gianneschi, Gregory P Holland and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Young Hun KimDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-3555-6573
Geoffray LericheDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
Karthik DiraviyamDepartment of Biomedical Engineering, Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Takaoki KoyanagiDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
Kaifu GaoSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-7574-4870
David OnofreiDepartment of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA.
Joseph PattersonDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
Anirvan GuhaAdolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, Fribourg, Switzerland.ORCID 0000-0001-6018-1438
Nathan GianneschiDepartments of Chemistry, Materials Science and Engineering, and Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0001-9945-5475
Gregory P HollandDepartment of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA.
Michael K GilsonSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-3375-1738
Michael MayerAdolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, Fribourg, Switzerland.ORCID 0000-0002-6148-5756
David SeptDepartment of Biomedical Engineering, Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-3719-2483
Jerry YangDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-8423-7376

Funding

THEORY AND MODELING OF NONCOVALENT BINDINGR01GM061300 · NIGMS · UNIVERSITY OF MD BIOTECHNOLOGY INSTITUTE · PI GILSON, MICHAEL K. · 2000 to 2021
$7.2M
NIGMS NIH HHS R01 GM061300
6 · The paper itself

Abstract

Maintaining membrane integrity is a challenge at extreme temperatures. Biochemical synthesis of membrane-spanning lipids is one adaptation that organisms such as thermophilic archaea have evolved to meet this challenge and preserve vital cellular function at high temperatures. The molecular-level details of how these tethered lipids affect membrane dynamics and function, however, remain unclear. Using synthetic monolayer-forming lipids with transmembrane tethers, here, we reveal that lipid tethering makes membrane permeation an entropically controlled process that helps to limit membrane leakage at elevated temperatures relative to bilayer-forming lipid membranes. All-atom molecular dynamics simulations support a view that permeation through membranes made of tethered lipids reduces the torsional entropy of the lipids and leads to tighter lipid packing, providing a molecular interpretation for the increased transition-state entropy of leakage.

Indexed as

EntropyHot TemperatureAdaptation, PhysiologicalArchaeaCalorimetry, Differential ScanningCell Membrane PermeabilityCryoelectron MicroscopyLipid BilayersLiposomesMicroscopy, Atomic ForceMolecular Dynamics SimulationLipid BilayersLiposomes

Identifiers

PMID31049402
PMCPMC6494508

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.