Evidence map›Paper›PMID 31049395›Full record

ArticleScience advances2019

Behavioral and epigenetic consequences of oxytocin treatment at birth.

W M Kenkel, A-M Perkeybile, J R Yee, H Pournajafi-Nazarloo, T S Lillard, E F Ferguson, K L Wroblewski, C F Ferris, C S Carter, J J Connelly

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. A Demographic History of a Prairie Vole (Microtus ochrogaster) Breeding Colony (2004-2020).Journal of the American Association for Laboratory Animal Science : JAALAS · 2026
    Article
  6. A Demographic History of a Prairie Vole (bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

W M KenkelKinsey Institute, Indiana University, Lindley Hall, 150 S. Woodlawn Avenue, Bloomington, IN 47405, USA.ORCID 0000-0002-0271-1071
A-M PerkeybileKinsey Institute, Indiana University, Lindley Hall, 150 S. Woodlawn Avenue, Bloomington, IN 47405, USA.
J R YeeKinsey Institute, Indiana University, Lindley Hall, 150 S. Woodlawn Avenue, Bloomington, IN 47405, USA.
H Pournajafi-NazarlooKinsey Institute, Indiana University, Lindley Hall, 150 S. Woodlawn Avenue, Bloomington, IN 47405, USA.ORCID 0000-0001-5562-7407
T S LillardDepartment of Psychology, University of Virginia, Charlottesville, VA 22903, USA.
E F FergusonDepartment of Psychology, University of Virginia, Charlottesville, VA 22903, USA.
K L WroblewskiDepartment of Psychology, University of Virginia, Charlottesville, VA 22903, USA.
C F FerrisDepartment of Psychology, Northeastern University, Boston, MA 02115, USA.ORCID 0000-0001-9744-5214
C S CarterKinsey Institute, Indiana University, Lindley Hall, 150 S. Woodlawn Avenue, Bloomington, IN 47405, USA.ORCID 0000-0001-5056-7740
J J ConnellyDepartment of Psychology, University of Virginia, Charlottesville, VA 22903, USA.ORCID 0000-0003-0443-0924
University of Virginia · USIndiana University Bloomington · USNortheastern University · USGeorgia State University · US

Funding

ImagingP01HD075750 · NICHD · TRUSTEES OF INDIANA UNIVERSITY · PI CARTER PORGES, CAROL SUE · 2014 to 2018
$4.3M
NICHD NIH HHS P01 HD075750
6 · The paper itself

Abstract

Oxytocin is used in approximately half of all births in the United States during labor induction and/or augmentation. However, the effects of maternal oxytocin administration on offspring development have not been fully characterized. Here, we used the socially monogamous prairie vole to examine the hypothesis that oxytocin exposure at birth can have long-term developmental consequences. Maternally administered oxytocin increased methylation of the oxytocin receptor (

Indexed as

AnimalsAnimals, NewbornArvicolinaeBehavior, AnimalBrainEpigenesis, GeneticFemaleMaleMethylationOxytocicsOxytocinParturitionPregnancyReceptors, OxytocinSocial BehaviorOxytocicsOxytocinReceptors, Oxytocin

Identifiers

PMID31049395
PMCPMC6494504
OpenAlexW2942604333

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.