ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2019
Nonparenchymal fluid is the source of increased mean diffusivity in preclinical Alzheimer's disease.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Leptomeninges: Anatomy, Mechanisms of Disease and Neuroimaging.Neurology international · 2025Review
- Diffusion Tensor Imaging in Neurofluids.Neuroimaging clinics of North America · 2025Review
- ISMRM Clinical Focus Meeting 2023: "Imaging the Fire in the Brain".Journal of magnetic resonance imaging : JMRI · 2025Article
- Perivascular and parenchymal fluid characteristics are related to age and cognitive performance across the lifespan.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Longitudinal effects of sex differences and apolipoprotein E genotype on white matter engagement among elderly.Brain communications · 2025Article
- Diffusion magnetic resonance imaging of cerebrospinal fluid dynamics: Current techniques and future advancements.NMR in biomedicine · 2024Review
- A comprehensive analysis of APOE genotype effects on human brain structure in the UK Biobank.Translational psychiatry · 2024Article
- Effects of sleep on brain perivascular space in a cognitively healthy population.Sleep medicine · 2023Article
- Imaging perivascular space structure and function using brain MRI.NeuroImage · 2022Review
- White Matter Free Water is a Composite Marker of Cerebral Small Vessel Degeneration.Translational stroke research · 2022Article
- Dilated perivascular space is related to reduced free-water in surrounding white matter among healthy adults and elderlies but not in patients with severe cerebral small vessel disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Three-dimensional self-attention conditional GAN with spectral normalization for multimodal neuroimaging synthesis.Magnetic resonance in medicine · 2021Article
- Global and Regional Changes in Perivascular Space in Idiopathic and Familial Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Recent Advances in Imaging of Preclinical, Sporadic, and Autosomal Dominant Alzheimer's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Volumetric distribution of perivascular space in relation to mild cognitive impairment.Neurobiology of aging · 2021Article
- Perivascular Space Imaging at Ultrahigh Field MR Imaging.Magnetic resonance imaging clinics of North America · 2021Review
- Diffusion Tensor Imaging of the Olfactory System in Older Adults With and Without Hyposmia.Frontiers in aging neuroscience · 2021Article
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Authors and funding
7 authors.
Funding
Abstract
introductionAlthough increased mean diffusivity of the white matter has been repeatedly linked to Alzheimer's disease pathology, the underlying mechanism is not known.
methodsHere, we used ADNI-3 multishell diffusion magnetic resonance imaging data to separate the diffusion signal of the parenchyma from less hindered fluid pools within the white matter such as perivascular space fluid and fluid-filled cavities.
resultsWe found that the source of the pathological increase of the mean diffusivity is the increased nonparenchymal fluid, often found in lacunes and perivascular spaces. In this cohort, the cognitive decline was significantly associated with the fluid increase and not with the microstructural changes of the white matter parenchyma itself. The white matter fluid increase was dominantly observed in the sagittal stratum and anterior thalamic radiation. DISCUSSION: These findings are positive steps toward understanding the pathophysiology of white matter alteration and its role in the cognitive decline.
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