Evidence map›Paper›PMID 31049361›Full record

ArticleJournal of immunology research2019

Cell Counts, rather than Proportion, of CD8/PD-1 Tumor-Infiltrating Lymphocytes in a Tumor Microenvironment Associated with Pathological Characteristics of Chinese Invasive Ductal Breast Cancer.

Qingkun Song, Feng Shi, Maya Adair, Hong Chang, Xiudong Guan, Yanjie Zhao, Yuchen Li, Guangjiang Wu, Jiangping Wu

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Qingkun SongDepartment of Science and Technology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.ORCID 0000-0002-1159-257X
Feng ShiDepartment of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Maya AdairUniversity of the Incarnate Word, San Antonio, TX 78209, USA.
Hong ChangDepartment of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Xiudong GuanBeijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
Yanjie ZhaoDepartment of Medical Oncology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Yuchen LiSid Faithfull Brain Cancer Research Laboratory, QIMR Berghofer Medical Research Institute, Locked Bag 2000 Royal Brisbane Hospital, QLD 4029, Australia.
Guangjiang WuDepartment of Infection Control, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Jiangping WuDepartment of Cancer Research, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Capital Medical University · CNQIMR Berghofer Medical Research Institute · AUUniversity of the Incarnate Word · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study is aimed at investigating the association of exhausted CD8

methods133 patients diagnosed with primary invasive ductal breast cancer were recruited into the cross-sectional study consecutively. Immunohistochemistry was used to detect biomarker expression on formalin-fixed and paraffin-embedded sections. Double staining of CD8 and PD-1 was conducted on lymphocytes.

resultsThe proportion of CD8

conclusionThe proportion of CD8

Indexed as

Tumor MicroenvironmentAgedAsian PeopleBreast NeoplasmsCarcinoma, Ductal, BreastCD8-Positive T-LymphocytesCell CountChinaCross-Sectional StudiesFemaleHumansKi-67 AntigenLymphocytes, Tumor-InfiltratingMiddle AgedProgrammed Cell Death 1 ReceptorRetrospective StudiesKi-67 AntigenProgrammed Cell Death 1 Receptor

Identifiers

PMID31049361
PMCPMC6462317
OpenAlexW2931760952

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.