Evidence map›Paper›PMID 31049328›Full record

ArticleOcular oncology and pathology2019

Uveal Melanoma in Ireland.

Caroline Baily, Valerie O'Neill, Mary Dunne, Moya Cunningham, Giuseppe Gullo, Susan Kennedy, Paul M Walsh, Sandra Deady, Noel Horgan

Abstract read
In one paragraph

Article in Ocular oncology and pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Global Incidence and Trend of Uveal Melanoma from 1943-2015: A Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2022
    Pooled it
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  18. The effects of exposure to solar radiation on human health.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Caroline BailyRoyal Victoria Eye and Ear Hospital, Dublin, Ireland.
Valerie O'NeillRoyal Victoria Eye and Ear Hospital, Dublin, Ireland.
Mary DunneClinical Trials Unit, St. Luke's Hospital, Dublin, Ireland.
Moya CunninghamSt. Luke's Hospital, Dublin, Ireland.
Giuseppe GulloSt. Vincent's University Hospital, Dublin, Ireland.
Susan KennedyRoyal Victoria Eye and Ear Hospital, Dublin, Ireland.
Paul M WalshNational Cancer Registry, Cork, Ireland.
Sandra DeadyNational Cancer Registry, Cork, Ireland.
Noel HorganRoyal Victoria Eye and Ear Hospital, Dublin, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo report the clinical features and epidemiology of uveal melanoma in Ireland.

methodsThis was an observational study of 253 patients with a new diagnosis of uveal melanoma between June 2010 and December 2015. Main outcome measures included demographics, clinical features, age-adjusted incidence, relative survival, overall survival, and distant metastases-free survival.

resultsThe mean patient age was 61.7 years. Tumour location was choroidal in 82%, ciliochoroidal in 9%, iridociliary in 2%, and iris in 7%. Treatment modalities included brachytherapy (ruthenium-106 and iodine-125 [64%]), enucleation (27%), and proton beam radiation (8%). The mean age-adjusted incidence of uveal melanoma in Ireland from 2010 to 2015 was 9.5 per million of the population (95% confidence interval [CI]: 8.4-10.7). Four-year relative survival was 81.3% (95% CI: 72.8-87.3). Four-year overall survival was 84% (95% CI: 78-90) and 4-year distant metastases-free survival was 79% (95% CI: 73-86).

conclusionBased on this data, the incidence of uveal melanoma in Ireland is high when compared with other reported incidence rates in Europe and worldwide. Relative and observed survival were in keeping with other reported European survival rates.

Indexed as

BrachytherapyChoroidEpidemiologyIncidenceMelanomaSurvival

Identifiers

PMID31049328
PMCPMC6489068

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.