Evidence map›Paper›PMID 31049285›Full record

ArticleLeukemia research reports2019

Central nervous system post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation: The Nagasaki transplant group experience.

Hikaru Sakamoto, Hidehiro Itonaga, Jun Taguchi, Takeharu Kato, Yasushi Sawayama, Tomayoshi Hayashi, Shiro Baba, Masako Moriuchi, Koichi Ohshima, Shinichiro Yoshida and 2 more

Erratum issuedAbstract readCase Reports
In one paragraph

Article in Leukemia research reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Hikaru SakamotoDepartment of Hematology, Nagasaki University Hospital, Nagasaki, Japan.
Hidehiro ItonagaDepartment of Hematology, Nagasaki University Hospital, Nagasaki, Japan.
Jun TaguchiDepartment of Hematology, Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan.
Takeharu KatoDepartment of Hematology, National Hospital Organization Nagasaki Medical Center, Omura, Japan.
Yasushi SawayamaDepartment of Hematology, Nagasaki University Hospital, Nagasaki, Japan.
Tomayoshi HayashiDepartment of Pathology, Nagasaki Prefecture Shimabara Hospital, Shimabara, Japan.
Shiro BabaDepartment of Neurosurgery, Nagasaki University Hospital, Nagasaki, Japan.
Masako MoriuchiDepartment of Pediatrics, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Koichi OhshimaDepartment of Pathology, School of Medicine, Kurume University, Kurume, Japan.
Shinichiro YoshidaDepartment of Hematology, National Hospital Organization Nagasaki Medical Center, Omura, Japan.
Yukiyoshi MoriuchiDepartment of Hematology, Sasebo City General Hospital, Sasebo, Japan.
Yasushi MiyazakiDepartment of Hematology, Nagasaki University Hospital, Nagasaki, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 17-year-old male received allogeneic transplantation for acute lymphoblastic leukemia, and presented with generalized seizures due to a solitary brain lesion with massive necrosis on day +621. Epstein-Barr virus (EBV) DNA copies were below the cut-off value in plasma. Stereotactic biopsy of the cerebral lesion confirmed the diagnosis of post-transplant lymphoproliferative disorder (PTLD) with large atypical cells positive for CD20 and EBER. In order to diagnose primary central nervous system PTLD, the biopsy should be applied as early as possible when brain lesion with necrosis develops in post-transplant patients regardless of EBV-DNA in plasma.

Indexed as

Allogeneic hematopoietic stem cell transplantationCentral nervous systemEpstein–Barr virusPost-transplant lymphoproliferative disorder

Identifiers

PMID31049285
PMCPMC6484211

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.