Evidence map›Paper›PMID 31049132›Full record

Trial reportOxidative medicine and cellular longevity2019

Uric Acid Provides Protective Role in Red Blood Cells by Antioxidant Defense: A Hypothetical Analysis.

Yunxiao Song, Li Tang, Jianping Han, Yanting Gao, Binghua Tang, Mingxi Shao, Wenhua Yuan, Wen Ge, Xiaofeng Huang, Tianyue Yao and 4 more

Open access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
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  6. Review
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  9. Article
  10. Pathway for ascertaining the role of uric acid in neurodegenerative diseases.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022
    Article
  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Yunxiao SongDepartment of Clinical Laboratory, Shanghai Xuhui Central Hospital, Shanghai, China.ORCID 0000-0002-0926-004X
Li TangDepartment of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.ORCID 0000-0002-2930-0862
Jianping HanDepartment of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.ORCID 0000-0002-2499-827X
Yanting GaoDepartment of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.ORCID 0000-0003-3131-9287
Binghua TangDepartment of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.ORCID 0000-0002-3248-4949
Mingxi ShaoDepartment of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.ORCID 0000-0002-2189-458X
Wenhua YuanDepartment of Clinical Laboratory, Shanghai Xuhui Central Hospital, Shanghai, China.ORCID 0000-0002-8253-9143
Wen GeDepartment of Clinical Laboratory, Shanghai Xuhui Central Hospital, Shanghai, China.ORCID 0000-0003-1391-6889
Xiaofeng HuangDepartment of Clinical Laboratory, Shanghai Xuhui Central Hospital, Shanghai, China.ORCID 0000-0003-3033-4493
Tianyue YaoDepartment of Clinical Laboratory, Shanghai Xuhui Central Hospital, Shanghai, China.ORCID 0000-0001-8632-9349
Xiaobo BianDepartment of Clinical Laboratory, Shanghai Xuhui Central Hospital, Shanghai, China.ORCID 0000-0002-3027-0234
Shengjie LiDepartment of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.ORCID 0000-0002-6443-740X
Wenjun CaoDepartment of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.ORCID 0000-0002-2355-2970
Haichen ZhangDepartment of Clinical Laboratory, Shanghai Xuhui Central Hospital, Shanghai, China.ORCID 0000-0001-9000-589X
Eye & ENT Hospital of Fudan University · CNShanghai Xuhui Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uric acid (UA) is a major antioxidant molecule in the human blood, and it has been linked with cell longevity. However, it is unclear whether serum UA levels are associated with red blood cell (RBC) indexes. This cross-sectional study included 10,759 Chinese subjects, recruited from the Shanghai Xuhui Central Hospital from January 2014 to December 2017. The participants were categorized into gender groups and then further divided into three different subgroups according to their UA reference range as follows: low (male (UA < 0.202 mmol/l), female (UA < 0.143 mmol/l)), normal (male (0.417 mmol/l > UA ≥ 0.202 mmol/l), female (0.339 mmol/l > UA ≥ 0.143 mmol/l)), and high (male (UA ≥ 0.417 mmol/l), female (UA ≥ 0.339 mmol/l)). The associations of UA levels with RBC parameters were analyzed using 1-way ANOVA, Pearson correlations, and multivariate linear regression. The levels of mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, RBCs, and hemoglobin were lowest in the low UA group, followed by the normal UA group and high UA group (

Indexed as

Sex CharacteristicsAdultAgedAntioxidantsCross-Sectional StudiesErythrocyte CountErythrocytesFemaleHumansMaleMiddle AgedUric AcidAntioxidantsUric Acid

Identifiers

PMID31049132
PMCPMC6458867
OpenAlexW2924105072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.