ArticleOpen access Macedonian journal of medical sciences2019
Thyroid Hormone Profile in Children with Sepsis: Does Euthyroid Sick Syndrome Exist?
Article in Open access Macedonian journal of medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Endocrine and metabolic alterations in response to systemic inflammation and sepsis: a review article.Molecular medicine (Cambridge, Mass.) · 2025Review
- Non-thyroidal Illness in Children with Congestive Heart FailureJournal of clinical research in pediatric endocrinology · 2024Article
- Decreased circulating levels of free triiodothyronine in Sepsis children and correlation analysis.BMC pediatrics · 2022Article
- Thyroid hormone disorders: a predictor of mortality in patients with septic shock defined by Sepsis-3?Internal and emergency medicine · 2021Observational
- Sepsis as a Pan-Endocrine Illness-Endocrine Disorders in Septic Patients.Journal of clinical medicine · 2021Review
- [Association of non-thyroidal illness syndrome with interleukin-6 and interleukin-10 in critically ill children with sepsis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundAlterations in peripheral thyroid hormone metabolism play an eminent role in the development of the euthyroid sick syndrome. Altered solvation may also lead to changes in peripheral thyroid hormones. Data on thyroid hormones in critically ill children remain unclear.
aimThis study was aimed to evaluate thyroid hormone profile in children with sepsis as well as to assess the association between thyroid level and sepsis outcome.
methodsAn observational cohort study was conducted in 80 children with sepsis from October 2015 to January 2016 in Haji Adam Malik General Hospital. T3 and T4 level were measured on day 1 and after > 72 hours of sepsis diagnosed.
resultsWe recorded length of stay in PICU, patient outcome and analysed the relationship with the chi-square test. Level of T3 and T4 were decreased on day 1 in pediatric sepsis. Of 80 subjects, 57 (71.2%) with low-level T3 and 41 (51.2%) with low T4 were found. The relationship between T3 and T4 level on day 1 with the length of stay were not found (P = 0.500; P = 0.987). There were a significant relationship between level of T3 and T4 with outcome (P = 0.0001; OR 24.706; P = 0.014; OR 3.086). Subject with normal T3 and T4 level had 24 and 3 times life chances compare to lower level.
conclusionThe Euthyroid Sick Syndrome in children with sepsis does exist. There was a significant relationship between T3 and T4 level on day 1 with patient outcome.
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