ArticleNeural plasticity2019
Dissociation between Cerebellar and Cerebral Neural Activities in Humans with Long-Term Bilateral Sensorineural Hearing Loss.
Article in Neural plasticity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- The Neglect of Recent Research on the Influence of the Cerebellum on Auditory Processing.Cerebellum (London, England) · 2026Review
- Cerebral blood flow alterations in non-auditory tinnitus: implications for cerebral venous congestion pathophysiology.Brain imaging and behavior · 2026Article
- Atrophy of cerebellum Crus I indicates poor outcome of cochlear implantation in the elderly.Scientific reports · 2025Article
- Establishing a robust triangulation framework to explore the relationship between hearing loss and Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation.Brain : a journal of neurology · 2024Article
- Engagement ofActa pharmaceutica Sinica. B · 2024Article
- The relationship between changes in functional connectivity gradients and cognitive-emotional disorders in sudden sensorineural hearing loss.Brain communications · 2024Article
- Combination of static and dynamic neural imaging features to distinguish sensorineural hearing loss: a machine learning study.Frontiers in neuroscience · 2024Article
- Emotional and Spontaneous Locomotor Behaviors Related to cerebellar Daidzein-dependent TrkB Expression Changes in Obese Hamsters.Cerebellum (London, England) · 2023Article
- Degree centrality and functional connections in presbycusis with and without cognitive impairments.Brain imaging and behavior · 2022Article
- Abnormal cerebellar network and effective connectivity in sudden and long-term sensorineural hearing loss.Frontiers in aging neuroscience · 2022Article
- Dynamic functional connections in leukoaraiosis patients without cognitive impairment: A pilot study.Frontiers in aging neuroscience · 2022Article
- Abnormal regional signal in the left cerebellum as a potential neuroimaging biomarker of sudden sensorineural hearing loss.Frontiers in psychiatry · 2022Article
- Aberrant Functional Network of Small-World in Sudden Sensorineural Hearing Loss With Tinnitus.Frontiers in neuroscience · 2022Article
- Aberrant brain functional network strength related to cognitive impairment in age-related hearing loss.Frontiers in neurology · 2022Article
- Disrupted intra- and inter-network connectivity in unilateral acute tinnitus with hearing loss.Frontiers in aging neuroscience · 2022Article
- Changes of the Brain Causal Connectivity Networks in Patients With Long-Term Bilateral Hearing Loss.Frontiers in neuroscience · 2021Article
- Abnormal Static and Dynamic Functional Network Connectivity in Patients With Presbycusis.Frontiers in aging neuroscience · 2021Article
- Silence, Solitude, and Serotonin: Neural Mechanisms Linking Hearing Loss and Social Isolation.Brain sciences · 2020Review
- Altered Functional Connectivity in Patients With Sloping Sensorineural Hearing Loss.Frontiers in human neuroscience · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormal neural activity in the cerebellum has been implicated in hearing impairments, but the effects of long-term hearing loss on cerebellar function are poorly understood. To further explore the role of long-term bilateral sensorineural hearing loss on cerebellar function, we investigated hearing loss-induced changes among neural networks within cerebellar subregions and the changes in cerebellar-cerebral connectivity patterns using resting-state functional MRI. Twenty-one subjects with long-term bilateral moderate-to-severe sensorineural hearing loss and 21 matched controls with clinically normal hearing underwent MRI scanning and a series of neuropsychological tests targeting cognition and emotion. Voxel-wise functional connectivity (FC) analysis demonstrated decreased couplings between the cerebellum and other cerebral areas, including the temporal pole (TP), insula, supramarginal gyrus, inferior frontal gyrus (IFG), medial frontal gyrus, and thalamus, in long-term bilateral sensorineural hearing loss patients. An ROI-wise FC analysis found weakened interregional connections within cerebellar subdivisions. Moreover, there was a negative correlation between anxiety and FC between the left cerebellar lobe VI and left insula. Hearing ability and anxiety scores were also correlated with FC between the left cerebellar lobe VI and left TP, as well as the right cerebellar lobule VI and left IFG. Our results suggest that sensorineural hearing loss disrupts cerebellar-cerebral circuits, some potentially linked to anxiety, and interregional cerebellar connectivity. The findings contribute to a growing body showing that auditory deprivation caused by cochlear hearing loss disrupts not only activity with the classical auditory pathway but also portions of the cerebellum that communicates with other cortical networks.
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