ArticleSaudi journal of biological sciences2019
Association between ENAM polymorphisms and dental caries in children.
Article in Saudi journal of biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Genetic Variants and Dental Caries Susceptibility: An Umbrella Review and Multilevel Meta-Analysis.Genes · 2026Pooled it
- [Polymorphisms associated with dental caries in pediatric populations: a systematic review].Revista medica del Instituto Mexicano del Seguro Social · 2023Pooled it
- Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis.BMC oral health · 2020Pooled it
- Integrative Analysis ofDentistry journal · 2026Article
- The association betweenHealth science reports · 2023Article
- AMELX and ENAM Polymorphisms and Dental Caries.International journal of dentistry · 2022Article
- Association of genetic variants in enamel-formation genes with dental caries: A meta- and gene-cluster analysis.Saudi journal of biological sciences · 2021Article
- ENAM Gene Variation in Students Exposed to Different Fluoride Concentrations.International journal of environmental research and public health · 2020Article
- Association of ENAM, TUFT1, MMP13, IL1B, IL10 and IL1RN gene polymorphism and dental caries susceptibility in Chinese children.The Journal of international medical research · 2019Article
- Analysis of ENAM gene single-nucleotide polymorphism rs3796704 with caries susceptibility in young adult Tamil population.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimDental enamel, the most rigid biological tissue of the tooth known to mankind, is the most integral and fundamental part of the tooth. Enamel matrixes compile 5% of Enamelin peptides and at the time of tooth development, they are considered to effect the formation and elongation of enamel crystallites. ENAM plays critical role in enamel formation. Any changes in ENAM may affect the thickness of enamel and may lead to dental caries. The present study is aimed to evaluate the association of ENAM gene polymorphisms and susceptibility of dental caries development risk. MATERIAL AND
methodsThe present study was carried out on 168 South Indian children, children's with dental caries were included in study. Written consent was taken from their parents/guardians. Additionally 193 healthy individuals were enrolled as controls. Sampling was done after dental examination of the individuals. Three ENAM gene single nucleotide polymorphisms (SNPs) were rs7671281, rs3796704 and rs12640848 was genotyped to check their role in susceptibility of dental caries development risk.
resultsOut of three SNPs rs7671281 showed statistically significant risk association with dental caries susceptibility in this ethnic population at heterozygous allele CT (OR: 1.939, p = .01865) and with minor allele T (OR: 1.451, p = .001292). SNP rs3796704 showed significant protective association with dental caries in Indian population at heterozygous allele GA (OR: 0.409, p = .0192) and with minor allele A (OR: 0.645, p = .00875). SNP rs12640848 showed significant protective association with dental caries in Indian population at heterozygous allele AG (OR: 3.041, p = .00642) and with minor allele G (OR: 1.478, p = .02184). Preliminary insilico analysis also showed that rs7671281 (Ile648Thr) amino acid change will cause the structural and functional changes in ENAM protein.
conclusionsIn the present study significant association was observed between ENAM gene SNP rs7671281 and dental caries susceptibility in South Indian children. These results suggested that ENAM gene variants may contribute to dental caries in children.
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