ArticlePLoS computational biology2019
Balance of mechanical forces drives endothelial gap formation and may facilitate cancer and immune-cell extravasation.
Article in PLoS computational biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 76 citations in OpenAlex.
- A continuous-discrete model of cell contraction incorporating actin and intermediate filaments.iScience · 2026Article
- Mechanobiology of solid tumor vasculature: implications for tumor progression.Cancer metastasis reviews · 2026Review
- Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Endothelial activation during the diapedesis of cancer cells: between the kiss of death and therapeutic breakthrough.Cellular & molecular biology letters · 2025Review
- Local soft niches in mechanically heterogeneous primary tumors promote brain metastasis via mechanotransduction-mediated HDAC3 activity.Science advances · 2025Article
- Nuclear envelope proteins, mechanotransduction, and their contribution to breast cancer progression.npj biological physics and mechanics · 2025Review
- Discrete network models of endothelial cells and their interactions with the substrate.Biomechanics and modeling in mechanobiology · 2024Article
- A mechanical modeling framework to study endothelial permeability.Biophysical journal · 2024Article
- The senescent secretome drives PLVAP expression in cultured human hepatic endothelial cells to promote monocyte transmigration.iScience · 2023Article
- Endothelium and Subendothelial Matrix Mechanics Modulate Cancer Cell Transendothelial Migration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Actomyosin contractility in olfactory placode neurons opens the skin epithelium to form the zebrafish nostril.Developmental cell · 2023Article
- Integrated role of human thymic stromal cells in hematopoietic stem cell extravasation.Bioengineering & translational medicine · 2023Article
- Paeonol Promotes Reendothelialization After Vascular Injury Through Activation of c-Myc/VEGFR2 Signaling Pathway.Drug design, development and therapy · 2023Article
- Mechanical stress driven by rigidity sensing governs epithelial stability.Nature physics · 2023Article
- Hybrid computational models of multicellular tumour growth considering glucose metabolism.Computational and structural biotechnology journal · 2023Review
- Feedback between mechanosensitive signaling and active forces governs endothelial junction integrity.Nature communications · 2022Article
- Substrate stiffness modulates migration and local intercellular membrane motion in pulmonary endothelial cell monolayers.American journal of physiology. Cell physiology · 2022Article
- A Stiff Extracellular Matrix Favors the Mechanical Cell Competition that Leads to Extrusion of Bacterially-Infected Epithelial Cells.Frontiers in cell and developmental biology · 2022Article
- Microfluidic model of monocyte extravasation reveals the role of hemodynamics and subendothelial matrix mechanics in regulating endothelial integrity.Biomicrofluidics · 2021Article
- BRAF Modulates Stretch-Induced Intercellular Gap Formation through Localized Actin Reorganization.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
Abstract
The formation of gaps in the endothelium is a crucial process underlying both cancer and immune cell extravasation, contributing to the functioning of the immune system during infection, the unfavorable development of chronic inflammation and tumor metastasis. Here, we present a stochastic-mechanical multiscale model of an endothelial cell monolayer and show that the dynamic nature of the endothelium leads to spontaneous gap formation, even without intervention from the transmigrating cells. These gaps preferentially appear at the vertices between three endothelial cells, as opposed to the border between two cells. We quantify the frequency and lifetime of these gaps, and validate our predictions experimentally. Interestingly, we find experimentally that cancer cells also preferentially extravasate at vertices, even when they first arrest on borders. This suggests that extravasating cells, rather than initially signaling to the endothelium, might exploit the autonomously forming gaps in the endothelium to initiate transmigration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.