Observational studyPloS one2019
Malnutrition, inflammation, progression of vascular calcification and survival: Inter-relationships in hemodialysis patients.
Observational study in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Comparative efficacy of nine exercise methods on the prognosis in chronic kidney disease patients with hemodialysis: a systematic review and network meta-analysis.European journal of medical research · 2023Pooled it
- Pooled it
- The efficacy of L-carnitine in improving malnutrition in patients on maintenance hemodialysis: a meta-analysis.Bioscience reports · 2020Pooled it
- A Novel Substrate-Inspired Fluorescence-Based Albumin Detection Improves Assessment of Clinical Outcomes in Hemodialysis Patients Receiving a Nursing Nutrition Intervention.Medical science monitor : international medical journal of experimental and clinical research · 2021Trial
- Targeting Vascular Calcification: Novel Insights into Molecular Pathways and Clinical Interventions.Cardiovascular drugs and therapy · 2026Review
- Article
- Latent Classes of Inflammation-Nutrition-Metabolism Status in Maintenance Hemodialysis: Associations with Arteriovenous Fistula Function and Cardiovascular Prognosis.Journal of multidisciplinary healthcare · 2026Article
- Association of C-reactive protein-albumin-lymphocyte index and coronary artery calcification on major adverse cardiovascular events of dialysis patients with acute coronary syndrome.Frontiers in immunology · 2026Article
- Serum magnesium and risk of arteriovenous fistula thrombosis in hemodialysis: a retrospective cohort study.BMC nephrology · 2025Article
- Endothelial injury is one of the risk factors for the progression of vascular calcification in patients receiving maintenance dialysis.Renal failure · 2025Article
- Klotho mediates the association between serum testosterone and severe abdominal aortic calcification: a cross-sectional study from the NHANES database.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Prognostic significance of abdominal aortic calcification scores on dual-energy X-ray absorptiometry scans for mortality in cancer survivors: NHANES-based cohort study (2013-2019).European heart journal open · 2025Article
- Extended-Hours Hemodialysis Without Dietary Restrictions Reduces Risk of Vascular Calcification.Journal of medical cases · 2025Article
- The Naples prognostic score as a new predictive index of severe abdominal aortic calcification: a population-based study.Frontiers in cardiovascular medicine · 2025Article
- Malnutrition and sarcopenia: a combined risk factor for vascular calcification and cardiovascular events in hemodialysis patients.Frontiers in nutrition · 2025Article
- The serum levels of gasdermin D in uremic patients and its relationship with the prognosis: a prospective observational cohort study.Renal failure · 2024Observational
- Construction of aRenal failure · 2024Article
- Abdominal aortic calcification among gastroenterological and transplant surgery.Annals of gastroenterological surgery · 2024Review
- Functional and prognostic impacts of serum albumin with thoracic arterial calcification among asymptomatic individuals.Scientific reports · 2024Article
- From Cells to Plaques: The Molecular Pathways of Coronary Artery Calcification and Disease.Journal of clinical medicine · 2024Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsMalnutrition and inflammation are closely linked to vascular calcification (VC), the severity of which correlate with adverse outcome. However, there were few studies on the interplay between malnutrition, inflammation and VC progression, rather than VC presence per se. We aimed to determine the relationship of malnutrition, inflammation, abdominal aortic calcification (AAC) progression with survival in hemodialysis (HD) patients.
methodsMalnutrition and inflammation were defined as low serum albumin (< 40 g/L) and high hs-CRP (≥ 28.57 nmol/L), respectively. We defined AAC progression as an increase in AAC score using lateral lumbar radiography at both baseline and one year later. Patients were followed up to investigate the impact of AAC progression on all-cause and cardiovascular mortality.
resultsAAC progressed in 54.6% of 97 patients (mean age 58.2±11.7 years, 41.2% men) at 1-year follow-up. Hypoalbuminemia (Odds ratio 3.296; 95% confidence interval 1.178-9.222), hs-CRP (1.561; 1.038-2.348), low LDL-cholesterol (0.976; 0.955-0.996), and the presence of baseline AAC (10.136; 3.173-32.386) were significant risk factors for AAC progression. During the mean follow-up period of 5.9 years, 38(39.2%) patients died and 27(71.0%) of them died of cardiovascular disease. Multivariate Cox regression analysis adjusted for old age, diabetes, cardiovascular history, and hypoalbuminemia determined that AAC progression was an independent predictor of all-cause mortality (2.294; 1.054-4.994).
conclusionsMalnutrition and inflammation were significantly associated with AAC progression. AAC progression is more informative than AAC presence at a given time-point as a predictor of all-cause mortality in patients on maintenance HD.
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