Evidence map›Paper›PMID 31048683›Full record

ArticleNature communications2019

Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation.

Sibylle Cocciardi, Anna Dolnik, Silke Kapp-Schwoerer, Frank G Rücker, Susanne Lux, Tamara J Blätte, Sabrina Skambraks, Jan Krönke, Florian H Heidel, Tina M Schnöder and 14 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 120 citations in OpenAlex.

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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 4 institutions in 1 country.

Sibylle CocciardiDepartment of Internal Medicine III, University Hospital of Ulm, Ulm, 89081, Germany.
Anna DolnikDepartment of Internal Medicine III, University Hospital of Ulm, Ulm, 89081, Germany.
Silke Kapp-SchwoererDepartment of Internal Medicine III, University Hospital of Ulm, Ulm, 89081, Germany.
Frank G RückerDepartment of Internal Medicine III, University Hospital of Ulm, Ulm, 89081, Germany.
Susanne LuxDepartment of Internal Medicine III, University Hospital of Ulm, Ulm, 89081, Germany.
Tamara J BlätteDepartment of Internal Medicine III, University Hospital of Ulm, Ulm, 89081, Germany.
Sabrina SkambraksDepartment of Internal Medicine III, University Hospital of Ulm, Ulm, 89081, Germany.
Jan KrönkeDepartment of Internal Medicine III, University Hospital of Ulm, Ulm, 89081, Germany.
Florian H HeidelDepartment of Internal Medicine II, Hematology and Oncology, Friedrich-Schiller-University Medical Center, Jena, 07743, Germany.
Tina M SchnöderDepartment of Internal Medicine II, Hematology and Oncology, Friedrich-Schiller-University Medical Center, Jena, 07743, Germany.
Andrea CorbaciogluDepartment of Internal Medicine III, University Hospital of Ulm, Ulm, 89081, Germany.
Verena I GaidzikDepartment of Internal Medicine III, University Hospital of Ulm, Ulm, 89081, Germany.
Peter PaschkaDepartment of Internal Medicine III, University Hospital of Ulm, Ulm, 89081, Germany.
Veronica TeleanuDepartment of Internal Medicine III, University Hospital of Ulm, Ulm, 89081, Germany.
Gudrun GöhringInstitute of Cell & Molecular Pathology, Hannover Medical School, Hannover, 30625, Germany.
Felicitas TholDepartment of Haematology, Haemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, 30625, Germany.
Michael HeuserDepartment of Haematology, Haemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, 30625, Germany.
Arnold GanserDepartment of Haematology, Haemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, 30625, Germany.
Daniela WeberDepartment of Internal Medicine III, University Hospital of Ulm, Ulm, 89081, Germany.
Eric SträngInstitute of Medical Systems Biology, Ulm University, Ulm, 30625, Germany.
Hans A KestlerInstitute of Medical Systems Biology, Ulm University, Ulm, 30625, Germany.ORCID http://orcid.org/0000-0002-4759-5254
Hartmut DöhnerDepartment of Internal Medicine III, University Hospital of Ulm, Ulm, 89081, Germany.
Lars BullingerDepartment of Internal Medicine III, University Hospital of Ulm, Ulm, 89081, Germany. lars.bullinger@charite.de.
Konstanze DöhnerDepartment of Internal Medicine III, University Hospital of Ulm, Ulm, 89081, Germany. konstanze.doehner@uniklinik-ulm.de.
University Hospital Ulm · DEMedizinische Hochschule Hannover · DELeibniz Institute on Aging - Fritz Lipmann Institute (FLI) · DEUniversität Ulm · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in the nucleophosmin 1 (NPM1) gene are considered founder mutations in the pathogenesis of acute myeloid leukemia (AML). To characterize the genetic composition of NPM1 mutated (NPM1

Indexed as

Clonal EvolutionAdultAgedDNA Mutational AnalysisExome SequencingFemaleHumansLeukemia, Myeloid, AcuteMaleMiddle AgedMutationNeoplasm Recurrence, LocalNeoplasms, Second PrimaryNuclear ProteinsNucleophosminNPM1 protein, humanNuclear ProteinsNucleophosmin

Identifiers

PMID31048683
PMCPMC6497712
OpenAlexW2943554095

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.