Evidence map›Paper›PMID 31048503›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Circadian clock regulation of the glycogen synthase (

Mokryun Baek, Stela Virgilio, Teresa M Lamb, Oneida Ibarra, Juvana Moreira Andrade, Rodrigo Duarte Gonçalves, Andrey Dovzhenok, Sookkyung Lim, Deborah Bell-Pedersen, Maria Celia Bertolini and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Circadian regulation of metabolism across photosynthetic organisms.The Plant journal : for cell and molecular biology · 2023
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Mokryun BaekDepartment of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, OH 45267-0575.
Stela VirgilioDepartamento de Bioquímica e Tecnologia Química, Instituto de Química, Universidade Estadual Paulista, 14800-060 Araraquara, SP, Brazil.
Teresa M LambDepartment of Biology, Texas A&M University, College Station, TX 77843-3258.
Oneida IbarraDepartment of Biology, Texas A&M University, College Station, TX 77843-3258.
Juvana Moreira AndradeDepartamento de Bioquímica e Tecnologia Química, Instituto de Química, Universidade Estadual Paulista, 14800-060 Araraquara, SP, Brazil.
Rodrigo Duarte GonçalvesDepartamento de Bioquímica e Tecnologia Química, Instituto de Química, Universidade Estadual Paulista, 14800-060 Araraquara, SP, Brazil.
Andrey DovzhenokDepartment of Mathematical Sciences, University of Cincinnati, Cincinnati, OH 45221.
Sookkyung LimDepartment of Mathematical Sciences, University of Cincinnati, Cincinnati, OH 45221.
Deborah Bell-PedersenDepartment of Biology, Texas A&M University, College Station, TX 77843-3258; dpedersen@bio.tamu.edu mcbertol@iq.unesp.br christian.hong@uc.edu.
Maria Celia BertoliniDepartamento de Bioquímica e Tecnologia Química, Instituto de Química, Universidade Estadual Paulista, 14800-060 Araraquara, SP, Brazil; dpedersen@bio.tamu.edu mcbertol@iq.unesp.br christian.hong@uc.edu.
Christian I HongDepartment of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, OH 45267-0575; dpedersen@bio.tamu.edu mcbertol@iq.unesp.br christian.hong@uc.edu.
Universidade Estadual Paulista (Unesp) · BRUniversity of Cincinnati · USTexas A&M University · US

Funding

Tools for Functional Analysis and Cell BiologyP01GM068087 · NIGMS · DARTMOUTH COLLEGE · PI DUNLAP, JAY C. · 2004 to 2013
$19.3M
Mechanisms of Circadian Clock Control of mRNA TranslationR35GM126966 · NIGMS · TEXAS A&M UNIVERSITY · PI Deborah Bell-Pedersen · 2018 to 2026
$6.6M
Molecular Genetic Analysis of Fungal Circadian RythmsR01GM058529 · NIGMS · TEXAS A&M UNIVERSITY SYSTEM · PI BELL-PEDERSEN, DEBORAH · 1999 to 2017
$4.6M
Systems Biology of the Circadian Clock Output NetworkR01GM113673 · NIGMS · TEXAS A&M UNIVERSITY · PI BELL-PEDERSEN, DEBORAH, GALAGAN, JAMES E · 2015 to 2018
$1.6M
Determining the Mechanism of Temperature Compensation of the Circadian ClockR01GM106426 · NIGMS · TEXAS A&M UNIVERSITY · PI BELL-PEDERSEN, DEBORAH · 2013 to 2016
$1.1M
NIGMS NIH HHS P01 GM068087NIGMS NIH HHS R01 GM058529NIGMS NIH HHS R01 GM106426NIGMS NIH HHS R01 GM113673NIGMS NIH HHS R35 GM126966
6 · The paper itself

Abstract

Circadian clocks generate rhythms in cellular functions, including metabolism, to align biological processes with the 24-hour environment. Disruption of this alignment by shift work alters glucose homeostasis. Glucose homeostasis depends on signaling and allosteric control; however, the molecular mechanisms linking the clock to glucose homeostasis remain largely unknown. We investigated the molecular links between the clock and glycogen metabolism, a conserved glucose homeostatic process, in

Indexed as

Circadian ClocksGene Expression RegulationFungal ProteinsGlycogenGlycogen SynthaseNeurospora crassaFungal ProteinsGlycogenGlycogen Synthasecircadian rhythmsglycogen metabolismglycogen phosphorylaseglycogen synthaseNeurospora crassa

Identifiers

PMID31048503
PMCPMC6534987
OpenAlexW2943570031

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.