ArticleCancer research2019
Thrombin Signaling Promotes Pancreatic Adenocarcinoma through PAR-1-Dependent Immune Evasion.
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In one paragraph
Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 2 pooled it
6.5field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Baseline D-dimer as a predictor of immune checkpoint inhibitor efficacy in cancer.Annals of medicine · 2026Pooled it
- Prognostic value of peripheral blood fibrinogen-to-albumin ratio in pancreatic cancer patients: a systematic review and meta-analysis.BMC cancer · 2026Pooled it
- The Cancer Immunotherapy Thromboembolism Assessment: A Novel Score for Predicting Thromboembolic Events in Melanoma Patients Treated With Immune Checkpoint Inhibition.International journal of cancer · 2026Article
- Integrated Proteomics and Metabolomics Analysis Reveals Potential Pathways Underlying Onion-Mediated Regulation of Spleen Immune Function in Liangshan Black Sheep.Veterinary sciences · 2026Article
- Structure-functionality relationship of collagen-fibrin interpenetrating hydrogels for engineered tumor-stroma models.Acta biomaterialia · 2026Article
- Prognostic and histologic significances of the expression profile of membrane tissue factor for aggressive endometrial carcinomas.The oncologist · 2026Article
- The unseen architects of metastasis: coagulation factors in pre-metastatic niche development.Cell communication and signaling : CCS · 2026Review
- Bidirectional regulatory mechanisms and therapeutic prospects of tumor hypercoagulable state and immunosuppressive tumor microenvironment.Oncology reviews · 2026Review
- Stromal fibrin shapes immune infiltration landscape of pancreatic ductal adenocarcinoma.Biomaterials · 2025Article
- Variations in Circulating Tumor Microenvironment-Associated Proteins in Non-Muscle Invasive Bladder Cancer Induced by Mitomycin C Treatment.International journal of molecular sciences · 2025Article
- The role of platelets in tumor immune evasion and metastasis: mechanisms and therapeutic implications.Cancer cell international · 2025Review
- D-dimer predicts the response of patients with gastric cancer to first-line immunotherapy combined with chemotherapy.Journal of gastrointestinal oncology · 2025Article
- MISP Suppresses Ferroptosis via MST1/2 Kinases to Facilitate YAP Activation in Non-Small Cell Lung Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Targeting uPAR with an antibody-drug conjugate suppresses tumor growth and reshapes the immune landscape in pancreatic cancer models.Science advances · 2025Article
- Prothrombin prevents fatal T cell-dependent anemia during chronic virus infection of mice.JCI insight · 2025Article
- Coagulation Protease-Driven Cancer Immune Evasion: Potential Targets for Cancer Immunotherapy.Cancers · 2024Review
- First-in-Class Humanized Antibody against Alternatively Spliced Tissue Factor Augments Anti-Metastatic Efficacy of Chemotherapy in a Preclinical Model of Pancreatic Ductal Adenocarcinoma.International journal of molecular sciences · 2024Article
- The Role of Tissue Factor In Signaling Pathways of Pathological Conditions and Angiogenesis.Current molecular medicine · 2024Review
- Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression.Molecular oncology · 2024Article
- Evaluation of Fluctuations ofMicroRNA (Shariqah, United Arab Emirates) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Yi YangDepartment of Biological Science and the Purdue Center for Cancer Research, Purdue University, West Lafayette, Indiana.ORCID 0000-0002-0219-2611
Amanda StangDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, Cincinnati, Ohio.
Patrick G SchweickertDepartment of Biological Science and the Purdue Center for Cancer Research, Purdue University, West Lafayette, Indiana.ORCID 0000-0001-9848-9278
Nadia A LanmanDepartment of Biological Science and the Purdue Center for Cancer Research, Purdue University, West Lafayette, Indiana.
Erin N PaulDepartment of Biological Science and the Purdue Center for Cancer Research, Purdue University, West Lafayette, Indiana.
Brett P MoniaIonis Pharmaceuticals, Inc., Antisense Drug Discovery, Carlsbad, California.
Alexey S RevenkoIonis Pharmaceuticals, Inc., Antisense Drug Discovery, Carlsbad, California.
Joseph S PalumboDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, Cincinnati, Ohio.
Eric S MullinsDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, Cincinnati, Ohio.
Bennett D ElzeyDepartment of Comparative Pathobiology, Purdue University, West Lafayette, Indiana.
Edith M JanssenDivision of Immunobiology, Cincinnati Children's Hospital, Cincinnati, Ohio.
Stephen F KoniecznyDepartment of Biological Science and the Purdue Center for Cancer Research, Purdue University, West Lafayette, Indiana. matthew.flick@cchmc.org sfk@purdue.edu.ORCID 0000-0002-3281-3714
Matthew J FlickDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, Cincinnati, Ohio. matthew.flick@cchmc.org sfk@purdue.edu.
Purdue University West Lafayette · USCincinnati Children's Hospital Medical Center · USIonis Pharmaceuticals (United States) · US
Funding
Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI Andrea L Kasinski · 1985 to 2026
$43.4MStem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4MTargeting the Plasminogen Activation System to Limit Pancreatic Cancer Progression and Associated ThrombosisU01HL143403 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FISHEL, MELISSA L., FLICK, MATTHEW J. · 2018 to 2022
$4.2MKras-Induced Cellular Plasticity in Pancreatic CancerR01CA124586 · NCI · PURDUE UNIVERSITY · PI KONIECZNY, STEPHEN F · 2008 to 2017
$3.1MThrombin-dependent mechanisms of pancreatic ductal adenocarcinoma diseaseR01CA211098 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FLICK, MATTHEW J. · 2017 to 2022
$2.2MCoagulation factors as modifiers of the colon cancer microenvironmentR01CA204058 · NCI · CINCINNATI CHILDRENS HOSP MED CTR · PI PALUMBO, JOSEPH S. · 2016 to 2020
$1.8MNCI NIH HHS P30 CA023168NCI NIH HHS R01 CA124586NCI NIH HHS R01 CA204058NCI NIH HHS R01 CA211098NHLBI NIH HHS U01 HL143403NIDDK NIH HHS P30 DK078392
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is associated with robust activity of the coagulation system. To determine mechanisms by which clotting factors influence PDAC tumor progression, we generated and characterized C57Bl/6-derived KPC (
Indexed as
AdenocarcinomaAnimalsCarcinoma, Pancreatic DuctalImmune EvasionMiceMice, Inbred C57BLMice, Inbred NODMice, SCIDPancreatic NeoplasmsReceptor, PAR-1Signal TransductionThrombinThromboplastinTumor Cells, CulturedTumor MicroenvironmentReceptor, PAR-1ThrombinThromboplastin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.