Observational studyBMJ open2019
Diabetes & Women's Health (DWH) Study: an observational study of long-term health consequences of gestational diabetes, their determinants and underlying mechanisms in the USA and Denmark.
Observational study in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Trial
- Reversal of canonical Wnt/β-catenin signaling pathway attenuates gestational diabetes mellitus-induced offspring cardiac hypertrophy: mechanistic insights into pathological remodeling.Nutrition & diabetes · 2026Article
- Article
- Review
- Article
- Pre-pregnancy inflammatory and insulinemic dietary patterns and risk of gestational diabetes mellitus: a prospective cohort study of 14,674 women.BMC medicine · 2025Article
- Regional differences in the prevalence of obstetric complications in relation to maternal obesity and food purchases.Acta obstetricia et gynecologica Scandinavica · 2025Observational
- Impact of parity on gestational diabetes mellitus in Chinese women: a retrospective cohort study.BMC pregnancy and childbirth · 2025Article
- Sleep Characteristics and Long-Term Risk of Type 2 Diabetes Among Women With Gestational Diabetes.JAMA network open · 2025Article
- Predicting Gestational Diabetes Mellitus in the first trimester using machine learning algorithms: a cross-sectional study at a hospital fertility health center in Iran.BMC medical informatics and decision making · 2025Article
- The Interplay of Persistent Organic Pollutants and Mediterranean Diet in Association With the Risk of Gestational Diabetes Mellitus.Diabetes care · 2024Article
- Vitamin D Prevents Gestational Diabetes Mellitus via Modulating Glucose Metabolism in a Mouse Model.Physiological research · 2024Article
- Precision stratification of prognostic risk factors associated with outcomes in gestational diabetes mellitus: a systematic review.Communications medicine · 2024Article
- Using the COM-B model and Behaviour Change Wheel to develop a theory and evidence-based intervention for women with gestational diabetes (IINDIAGO).BMC public health · 2023Article
- miR-24-3p and Body Mass Index as Type 2 Diabetes Risk Factors in Spanish Women 15 Years after Gestational Diabetes Mellitus Diagnosis.International journal of molecular sciences · 2023Article
- Pre-kidney Donation Pregnancy Complications and Long-term Outcomes.Transplantation · 2022Article
- Modifiable risk factors and long term risk of type 2 diabetes among individuals with a history of gestational diabetes mellitus: prospective cohort study.BMJ (Clinical research ed.) · 2022Article
- A Scoping Review on Gestational Diabetes in Hawai'i: A "Window of Opportunity" to Address Intergenerational Risk for Type 2 Diabetes Mellitus.Hawai'i journal of health & social welfare · 2022Article
- An early model to predict the risk of gestational diabetes mellitus in the absence of blood examination indexes: application in primary health care centres.BMC pregnancy and childbirth · 2021Article
- Intergenerational Associations Between Maternal Diet and Childhood Adiposity: A Bayesian Regularized Mediation Analysis.Statistics in biosciences · 2021Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
purposeWomen who experience gestational diabetes mellitus (GDM) are at exceptionally high-risk of developing type 2 diabetes (T2DM) later in life. However, limited information is available about genetic and environmental factors that are implicated in the progression from GDM to T2DM.
participantsThe Diabetes & Women's Health (DWH) Study applied a hybrid design, which combined new prospective data collection with existing data in two prospective cohorts, the Danish National Birth Cohort (DNBC) and the Nurses' Health Study II (NHS II). In total, the DWH Study identified 7759 women with a GDM diagnosis from both cohorts; 4457 women participated in the DWH Study data collection, which included two cycles of follow-up from 2012 to 2014 and 2014 to 2016. FINDINGS TO DATE: Progression from GDM to T2DM was high. In the NHS II group, by 2013, 23.1% (n=846/3667) developed T2DM. In the DNBC group, at cycle 1 (2012-2014), the progression rate was even higher: 27.2% (n=215/790) had developed T2DM. Furthermore, we have shown that women who had GDM experienced a significantly greater risk of hypertension and cardiovascular diseases, as well as early stages of glomerular hyperfiltration and renal damage. Moreover, the DWH Study findings have shown that healthful diet and lifestyle factors and weight control were related to a lower risk of T2DM, hypertension and cardiovascular diseases. FUTURE PLANS: Primary data collection for the DWH Study is complete and investigators are currently investigating interactions of the abovementioned modifiable factors with T2DM genetic susceptibility in determining the risk of progression from GDM to T2DM. Findings from ongoing work will provide further insights for identifying more precise prevention strategies for T2DM and comorbidities in this high-risk population. Future work will examine novel biomarkers of health and disease in this cohort.
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