Evidence map›Paper›PMID 31048406›Full record

ArticleJournal of lipid research2019

Human COQ10A and COQ10B are distinct lipid-binding START domain proteins required for coenzyme Q function.

Hui S Tsui, Nguyen V B Pham, Brendan R Amer, Michelle C Bradley, Jason E Gosschalk, Marcus Gallagher-Jones, Hope Ibarra, Robert T Clubb, Crysten E Blaby-Haas, Catherine F Clarke

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. An origin for a eukaryotic lipid transfer protein fold in Asgard archaea.bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Gene Expression Dysregulation in Whole Blood of Patients withInternational journal of molecular sciences · 2024
    Article
  9. Article
  10. Article
  11. Primary Coenzyme Q10 Deficiency: An Update.Antioxidants (Basel, Switzerland) · 2023
    Review
  12. Biosynthesis, Deficiency, and Supplementation of Coenzyme Q.Antioxidants (Basel, Switzerland) · 2023
    Review
  13. New Insights on the Uptake and Trafficking of Coenzyme Q.Antioxidants (Basel, Switzerland) · 2023
    Review
  14. Coenzyme Q biochemistry and biosynthesis.Trends in biochemical sciences · 2023
    Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Hui S TsuiDepartment of Chemistry and Biochemistry and Molecular Biology Institute,University of California, Los Angeles, Los Angeles, CA 90095.
Nguyen V B PhamDepartment of Chemistry and Biochemistry and Molecular Biology Institute,University of California, Los Angeles, Los Angeles, CA 90095.
Brendan R AmerDepartment of Chemistry and Biochemistry and Molecular Biology Institute,University of California, Los Angeles, Los Angeles, CA 90095.
Michelle C BradleyDepartment of Chemistry and Biochemistry and Molecular Biology Institute,University of California, Los Angeles, Los Angeles, CA 90095.
Jason E GosschalkDepartment of Chemistry and Biochemistry and Molecular Biology Institute,University of California, Los Angeles, Los Angeles, CA 90095.
Marcus Gallagher-JonesDepartment of Chemistry and Biochemistry and Molecular Biology Institute,University of California, Los Angeles, Los Angeles, CA 90095.
Hope IbarraDepartment of Chemistry and Biochemistry and Molecular Biology Institute,University of California, Los Angeles, Los Angeles, CA 90095.
Robert T ClubbDepartment of Chemistry and Biochemistry and Molecular Biology Institute,University of California, Los Angeles, Los Angeles, CA 90095.
Crysten E Blaby-HaasDepartment of Biology Brookhaven National Laboratory, Upton, NY 11973.
Catherine F ClarkeDepartment of Chemistry and Biochemistry and Molecular Biology Institute,University of California, Los Angeles, Los Angeles, CA 90095 cathy@chem.ucla.edu.
University of California, Los Angeles · USBrookhaven National Laboratory · US

Funding

UCLA NIGMS T32 Program AssessmentT32GM007185 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 1985 to 2020
$21.7M
Cell Surface Protein Anchoring in Gram-Positive BacteriaR01AI052217 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert Thompson Clubb · 2002 to 2026
$8.5M
CHEMISTRY BIOLOGY INTERFACE TRAINING PROGRAMT32GM008496 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYNARD, HEATHER D · 1993 to 2019
$6.3M
NIAID NIH HHS R01 AI052217NIGMS NIH HHS T32 GM007185NIGMS NIH HHS T32 GM008496
6 · The paper itself

Abstract

Coenzyme Q (CoQ or ubiquinone) serves as an essential redox-active lipid in respiratory electron and proton transport during cellular energy metabolism. CoQ also functions as a membrane-localized antioxidant protecting cells against lipid peroxidation. CoQ deficiency is associated with multiple human diseases; CoQ

Indexed as

AntioxidantsAtaxiaHumansLipid PeroxidationMass SpectrometryMitochondriaMitochondrial DiseasesMuscle WeaknessOxidative StressPhosphoproteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSteroidogenic Acute Regulatory ProteinUbiquinoneAntioxidantscoenzyme Q10PhosphoproteinsSaccharomyces cerevisiae ProteinsSteroidogenic Acute Regulatory ProteinUbiquinoneantioxidantslipids/chemistrylipids/peroxidationmass spectrometrymitochondriaSaccharomyces cerevisiaesteroidogenic acute regulatory protein-related lipid transferubiquinone

Identifiers

PMID31048406
PMCPMC6602128
OpenAlexW2943082710

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.