Evidence map›Paper›PMID 31048357›Full record

ArticleHaematologica2020

Multilayer intraclonal heterogeneity in chronic myelomonocytic leukemia.

Allan Beke, Lucie Laplane, Julie Riviere, Qin Yang, Miguel Torres-Martin, Thibault Dayris, Philippe Rameau, Veronique Saada, Chrystèle Bilhou-Nabera, Ana Hurtado and 5 more

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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  3. Inherited KDM6AOncogene · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Allan BekeINSERM U1170, Gustave Roussy Cancer Center, Villejuif, France.
Lucie LaplaneINSERM U1170, Gustave Roussy Cancer Center, Villejuif, France.
Julie RiviereINSERM U1170, Gustave Roussy Cancer Center, Villejuif, France.
Qin YangHuman Genetics, University of Miami Miller School of Medicine, Miami, FL, USA.
Miguel Torres-MartinHuman Genetics, University of Miami Miller School of Medicine, Miami, FL, USA.
Thibault DayrisCNRS 3655 & INSERM US23, AMMICa, Gustave Roussy Cancer Center, Villejuif, France.
Philippe RameauCNRS 3655 & INSERM US23, AMMICa, Gustave Roussy Cancer Center, Villejuif, France.
Veronique SaadaDepartment of Biopathology, Gustave Roussy Cancer Center, Villejuif, France.
Chrystèle Bilhou-NaberaService d'Hématologie Biologique, Hôpital Saint-Antoine, Paris, France.
Ana HurtadoHematology and Medical Oncology Department, Hospital Morales Meseguer, IMIB, Murcia, Spain.
Larissa LordierINSERM U1170, Gustave Roussy Cancer Center, Villejuif, France.
William VainchenkerINSERM U1170, Gustave Roussy Cancer Center, Villejuif, France.
Maria E FigueroaHuman Genetics, University of Miami Miller School of Medicine, Miami, FL, USA.
Nathalie DroinINSERM U1170, Gustave Roussy Cancer Center, Villejuif, France.
Eric SolaryINSERM U1170, Gustave Roussy Cancer Center, Villejuif, France eric.solary@gustaveroussy.fr.
Institut Gustave Roussy · FRInserm · FRUniversity of Miami · USHospital General Universitario Morales Meseguer · ESSorbonne Université · FRSylvester Comprehensive Cancer Center · US

Funding

Tumor Biology Research ProgramP30CA240139 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI George S. Grills · 2019 to 2026
$24.1M
NCI NIH HHS P30 CA240139
6 · The paper itself

Abstract

The functional diversity of cells that compose myeloid malignancies, i.e., the respective roles of genetic and epigenetic heterogeneity in this diversity, remains poorly understood. This question is addressed in chronic myelomonocytic leukemia, a myeloid neoplasm in which clinical diversity contrasts with limited genetic heterogeneity. To generate induced pluripotent stem cell clones, we reprogrammed CD34

Indexed as

Leukemia, Myelomonocytic, ChronicLeukemia, Myelomonocytic, JuvenileMyeloproliferative DisordersExome SequencingHumansMutation

Identifiers

PMID31048357
PMCPMC6939510
OpenAlexW2942853023

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.