Evidence map›Paper›PMID 31048107›Full record

ArticleVirology2019

Differential recognition of peptides within feline coronavirus polyprotein 1 ab by sera from healthy cats and cats with feline infectious peritonitis.

Anastasia Chernyavtseva, Nick J Cave, John S Munday, Magdalena Dunowska

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07667478 (NON-INVASIVE BRAIN STIMULATION FOR MEMORY LOSS IN EARLY ALZHEIMER'S DISEASE), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07667478 narecruitingnot on this mapstarted 2026, after this paper: background citation

Non-invasive brain stimulation for memory loss in early alzheimer's disease

TypeinterventionalSponsorChi-Ying (Roy) LinRan2026 to 2031Enrolled40ConditionsAlzheimer s Disease, Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease, Mild DementiaArmsrepetitive transcranial magnetic stimulation (rTMS), sham repetitive transcranial magnetic stimulation rTMS
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anastasia ChernyavtsevaSchool of Veterinary Science, Massey University, Palmerston North, New Zealand.
Nick J CaveSchool of Veterinary Science, Massey University, Palmerston North, New Zealand.
John S MundaySchool of Veterinary Science, Massey University, Palmerston North, New Zealand.
Magdalena DunowskaSchool of Veterinary Science, Massey University, Palmerston North, New Zealand. Electronic address: M.Dunowska@massey.ac.nz.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the study was to identify peptides within the polyprotein (Pp) 1 ab that are differentially recognised by cats with either enteric or systemic disease following infection with feline coronavirus. Overlapping 12-mer peptides (n = 28,426) across the entire Pp1ab were arrayed on peptide chips and reacted with pooled sera from coronavirus seropositive cats and from one seronegative cat. Eleven peptides were further tested in ELISA with individual serum samples, and three were selected for further screening. Two peptides (16433 and 4934) in the nsp3 region encoding the papain 1 and 2 proteases were identified for final testing. Peptide 4934 reacted equally with positive sera from healthy cats and cats with feline infectious peritonitis (FIP), while peptide 16433 was recognized predominantly by FIP-affected cats. The value of antibody tests based on these peptides in differentiating between the enteric and FIP forms of feline coronavirus infection remains to be determined.

Indexed as

AnimalsAntibodies, ViralAntibody SpecificityCatsCoronavirus, FelineEpitopesFeline Infectious PeritonitisFemaleGene ExpressionImmune SeraMalePeptide MappingPeptidesPolyproteinsProtein BindingViral ProteinsAntibodies, ViralEpitopesImmune SeraPeptidesPolyproteinsViral ProteinsAntibody responseFeline coronavirusFeline enteric coronavirusFeline infectious peritonitisFIPNon-structural proteins

Identifiers

PMID31048107
PMCPMC7112048

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.