Evidence map›Paper›PMID 31047999›Full record

ArticleToxicology letters2019

Phosgene inhalation causes hemolysis and acute lung injury.

Saurabh Aggarwal, Tamas Jilling, Stephen Doran, Israr Ahmad, Jeannette E Eagen, Stephen Gu, Mark Gillespie, Carolyn J Albert, David Ford, Joo-Yeun Oh and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Toxicology letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Hemopexin reverses activation of lung eIF2α and decreases mitochondrial injury in chlorine-exposed mice.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  6. Countermeasures against Pulmonary Threat Agents.The Journal of pharmacology and experimental therapeutics · 2024
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Halogen exposure injury in the developing lung.Annals of the New York Academy of Sciences · 2020
    Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Saurabh AggarwalDepartment of Anesthesiology and Perioperative Medicine, Birmingham, AL, 35205-3703, United States; Division of Molecular and Translational Biomedicine, Birmingham, AL, 35205-3703, United States; Pulmonary Injury and Repair Center, Birmingham, AL, 35205-3703, United States; Center for Free Radical Biology, Birmingham, AL, 35205-3703, United States; School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35205-3703, United States; University of South Alabama Health College of Medicine, Mobile, AL, United States; St. Louis University, St. Louis, MO, 63104, United States.
Tamas JillingPulmonary Injury and Repair Center, Birmingham, AL, 35205-3703, United States; Department of Pediatrics, Division of Neonatology, Birmingham, AL, 35205-3703, United States; Center for Free Radical Biology, Birmingham, AL, 35205-3703, United States; School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35205-3703, United States; University of South Alabama Health College of Medicine, Mobile, AL, United States; St. Louis University, St. Louis, MO, 63104, United States.
Stephen DoranDepartment of Anesthesiology and Perioperative Medicine, Birmingham, AL, 35205-3703, United States; Division of Molecular and Translational Biomedicine, Birmingham, AL, 35205-3703, United States; School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35205-3703, United States; University of South Alabama Health College of Medicine, Mobile, AL, United States; St. Louis University, St. Louis, MO, 63104, United States.
Israr AhmadDepartment of Anesthesiology and Perioperative Medicine, Birmingham, AL, 35205-3703, United States; Division of Molecular and Translational Biomedicine, Birmingham, AL, 35205-3703, United States; School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35205-3703, United States; University of South Alabama Health College of Medicine, Mobile, AL, United States; St. Louis University, St. Louis, MO, 63104, United States.
Jeannette E EagenDepartment of Anesthesiology and Perioperative Medicine, Birmingham, AL, 35205-3703, United States; Division of Molecular and Translational Biomedicine, Birmingham, AL, 35205-3703, United States; School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35205-3703, United States; University of South Alabama Health College of Medicine, Mobile, AL, United States; St. Louis University, St. Louis, MO, 63104, United States.
Stephen GuDepartment of Anesthesiology and Perioperative Medicine, Birmingham, AL, 35205-3703, United States; Division of Molecular and Translational Biomedicine, Birmingham, AL, 35205-3703, United States; School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35205-3703, United States; University of South Alabama Health College of Medicine, Mobile, AL, United States; St. Louis University, St. Louis, MO, 63104, United States.
Mark GillespieSchool of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35205-3703, United States; Department of Pharmacology, Mobile, AL, United States; University of South Alabama Health College of Medicine, Mobile, AL, United States; St. Louis University, St. Louis, MO, 63104, United States.
Carolyn J AlbertSchool of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35205-3703, United States; University of South Alabama Health College of Medicine, Mobile, AL, United States; Department of Biochemistry and Molecular Biology, St. Louis, MO, 63104, United States; St. Louis University, St. Louis, MO, 63104, United States.
David FordSchool of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35205-3703, United States; University of South Alabama Health College of Medicine, Mobile, AL, United States; Department of Biochemistry and Molecular Biology, St. Louis, MO, 63104, United States.
Joo-Yeun OhDepartment of Pathology, Division of Cellular and Molecular Pathology, Birmingham, AL, 35205-3703, United States; Center for Free Radical Biology, Birmingham, AL, 35205-3703, United States; School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35205-3703, United States; University of South Alabama Health College of Medicine, Mobile, AL, United States; St. Louis University, St. Louis, MO, 63104, United States.
Rakesh P PatelPulmonary Injury and Repair Center, Birmingham, AL, 35205-3703, United States; Department of Pathology, Division of Cellular and Molecular Pathology, Birmingham, AL, 35205-3703, United States; Center for Free Radical Biology, Birmingham, AL, 35205-3703, United States; University of South Alabama Health College of Medicine, Mobile, AL, United States; St. Louis University, St. Louis, MO, 63104, United States.
Sadis MatalonDepartment of Anesthesiology and Perioperative Medicine, Birmingham, AL, 35205-3703, United States; Division of Molecular and Translational Biomedicine, Birmingham, AL, 35205-3703, United States; Pulmonary Injury and Repair Center, Birmingham, AL, 35205-3703, United States; Center for Free Radical Biology, Birmingham, AL, 35205-3703, United States; University of South Alabama Health College of Medicine, Mobile, AL, United States; St. Louis University, St. Louis, MO, 63104, United States. Electronic address: smatalon@uabmc.edu.
University of Alabama at Birmingham · USUniversity of Missouri–St. Louis · US

Funding

Bromine Inhalation Induced Lung Injury: Novel Mechanisms and Treatment StrategiesU01ES026458 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MATALON, SADIS · 2015 to 2019
$3.9M
CIALIS® reverses halogen induced injury to pregnant animals and their offspringU01ES027697 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JILLING, TAMAS SANDOR, MATALON, SADIS · 2016 to 2020
$3.7M
NIEHS NIH HHS U01 ES026458NIEHS NIH HHS U01 ES027697
6 · The paper itself

Abstract

Phosgene (Carbonyl Chloride, COCl

Indexed as

Acute Lung InjuryAdministration, InhalationAnimalsChemical Warfare AgentsFemaleHemolysisMaleMiceMice, Inbred C57BLPhosgeneChemical Warfare AgentsPhosgeneBAL proteinsFree hemeInflammationPlasmalogensRed blood cell fragility

Identifiers

PMID31047999
PMCPMC6653688
OpenAlexW2950547036

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.