Evidence map›Paper›PMID 31047981›Full record

ArticleToxicology and applied pharmacology2019

Enrichment of genes associated with squamous differentiation in cancer initiating cells isolated from urothelial cells transformed by the environmental toxicant arsenite.

Zachary E Hoggarth, Danyelle B Osowski, Andrea Slusser-Nore, Swojani Shrestha, Prakash Pathak, Theoren Solseng, Scott H Garrett, Divyen H Patel, Evan Savage, Donald A Sens and 1 more

Open access · greenAbstract read
In one paragraph

Article in Toxicology and applied pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Cell cycle (Georgetown, Tex.) · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Zachary E HoggarthDepartment of Pathology, University of North Dakota, School of Medicine and Health Sciences, 1301 N. Columbia Road, Stop 9037, Grand Forks, ND 58202, United States. Electronic address: zachary.hoggarth@und.edu.
Danyelle B OsowskiDepartment of Pathology, University of North Dakota, School of Medicine and Health Sciences, 1301 N. Columbia Road, Stop 9037, Grand Forks, ND 58202, United States. Electronic address: danyelle.osowski@und.edu.
Andrea Slusser-NoreDepartment of Pathology, University of North Dakota, School of Medicine and Health Sciences, 1301 N. Columbia Road, Stop 9037, Grand Forks, ND 58202, United States. Electronic address: andrea.slusser@und.edu.
Swojani ShresthaDepartment of Pathology, University of North Dakota, School of Medicine and Health Sciences, 1301 N. Columbia Road, Stop 9037, Grand Forks, ND 58202, United States. Electronic address: swojani.shrestha@und.edu.
Prakash PathakDepartment of Pathology, University of North Dakota, School of Medicine and Health Sciences, 1301 N. Columbia Road, Stop 9037, Grand Forks, ND 58202, United States. Electronic address: prakash.pathak@und.edu.
Theoren SolsengDepartment of Pathology, University of North Dakota, School of Medicine and Health Sciences, 1301 N. Columbia Road, Stop 9037, Grand Forks, ND 58202, United States. Electronic address: theoren.solseng@und.edu.
Scott H GarrettDepartment of Pathology, University of North Dakota, School of Medicine and Health Sciences, 1301 N. Columbia Road, Stop 9037, Grand Forks, ND 58202, United States. Electronic address: scott.garrett@med.und.edu.
Divyen H PatelGenome Explorations, 1910 Nonconnah Avenue, Suite 120, Memphis, TN 38132, United States. Electronic address: dpatel@genome-explorations.com.
Evan SavageGenome Explorations, 1910 Nonconnah Avenue, Suite 120, Memphis, TN 38132, United States. Electronic address: esavage@genome-explorations.com.
Donald A SensDepartment of Pathology, University of North Dakota, School of Medicine and Health Sciences, 1301 N. Columbia Road, Stop 9037, Grand Forks, ND 58202, United States. Electronic address: donald.sens@med.und.edu.
Seema SomjiDepartment of Pathology, University of North Dakota, School of Medicine and Health Sciences, 1301 N. Columbia Road, Stop 9037, Grand Forks, ND 58202, United States. Electronic address: seema.somji@med.und.edu.
University of North Dakota · USCollege of Exploration · US

Funding

Research CoresP20GM103442 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI Donald A. Sens · 2012 to 2026
$53.0M
NIGMS NIH HHS P20 GM103442
6 · The paper itself

Abstract

Arsenic is an environmental toxicant with long-term exposure associated with the development of urothelial carcinomas. Our lab has developed an in-vitro model of urothelial carcinoma by exposing the immortal, but non-tumorigenic bladder cell line, the UROtsa, to arsenite (As

Indexed as

ArsenitesBiomarkers, TumorCell Line, TumorCell Transformation, NeoplasticCluster AnalysisEpigenesis, GeneticEpithelial CellsGene Expression Regulation, NeoplasticHumansNeoplasms, Squamous CellProtein Array AnalysisUrinary Bladder NeoplasmsUrotheliumarseniteArsenitesBiomarkers, TumorArseniteSquamous differentiationStem cellsUrothelial cell carcinomaUROtsa

Identifiers

PMID31047981
PMCPMC6724223
OpenAlexW2943112883

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.