Evidence map›Paper›PMID 31047953›Full record

ReviewChest2020

Apneas of Heart Failure and Phenotype-Guided Treatments: Part One: OSA.

Shahrokh Javaheri, Lee K Brown, William T Abraham, Rami Khayat

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Chest, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
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  6. Article
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  9. Article
  10. Review
  11. Article
  12. Review
  13. Observational
  14. In patients with heart failure, enhanced ventilatory response to exercise is associated with severe obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021
    Article
  15. Article
  16. Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Shahrokh JavaheriDivision of Pulmonary and Sleep Medicine, Bethesda North Hospital, Cincinnati, OH; University of Cincinnati College of Medicine, Cincinnati, OH. Electronic address: shahrokhjavaheri@icloud.com.
Lee K BrownDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM; Program in Sleep Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM; Department of Electrical and Computer Engineering, University of New Mexico School of Engineering, Albuquerque, NM.
William T AbrahamDivision of Cardiovascular Medicine, The Ohio State University, Columbus, OH.
Rami KhayatThe Sleep Heart Program, The Ohio State University, Columbus, OH; Division of Pulmonary Critical Care and Sleep, The Ohio State University, Columbus, OH.
The Ohio State University · USBethesda North Hospital · USUniversity of New Mexico · US

Funding

Impact of Low Flow Nocturnal Oxygen Therapy On Hospital Readmission/Mortalityin Patients with Heart Failure and Central Sleep Apneal (LOFT-HF)UG3HL140144 · NHLBI · OHIO STATE UNIVERSITY · PI ABRAHAM, WILLIAM TOBER · 2018 to 2018
$742k
NHLBI NIH HHS UG3 HL140144
6 · The paper itself

Abstract

Sleep-disordered breathing (SDB), including OSA and central sleep apnea, is highly prevalent in patients with heart failure (HF). Multiple studies have reported this high prevalence in asymptomatic as well as symptomatic patients with reduced left ventricular ejection fraction (HFrEF), as well as in those with HF with preserved ejection fraction. The acute pathobiologic consequences of OSA, including exaggerated sympathetic activity, oxidative stress, and inflammation, eventually could lead to progressive left ventricular dysfunction, repeated hospitalization, and excessive mortality. Large numbers of observational studies and a few small randomized controlled trials have shown improvement in various cardiovascular consequences of SDB with treatment. There are no long-term randomized controlled trials to show improved survival of patients with HF and treatment of OSA. One trial of positive airway pressure treatment of OSA included patients with HF and showed no improvement in clinical outcomes. However, any conclusions derived from this trial must take into account several important pitfalls that have been extensively discussed in the literature. With the role of positive airway pressure as the sole therapy for SDB in HF increasingly questioned, a critical examination of long-accepted concepts in this field is needed. The objective of this review was to incorporate recent advances in the field into a phenotype-based approach to the management of OSA in HF.

Indexed as

Electric Stimulation TherapyAcetazolamideCarbon DioxideCarbonic Anhydrase InhibitorsContinuous Positive Airway PressureExerciseHeart FailureHumansHypoglossal NerveMuscle HypotoniaOxygen Inhalation TherapyPharyngeal MusclesPhenotypeSleep Apnea, ObstructiveAcetazolamideCarbon DioxideCarbonic Anhydrase Inhibitorsadaptive servo-ventilationcentral sleep apneaheart failureHunter-Cheyne-Stokes breathingnoninvasive ventilationoxygenpositive airway pressure

Identifiers

PMID31047953
PMCPMC7005380
OpenAlexW2943808360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.