ArticleMolecular and cellular biology1987
Regulation of human T-lymphocyte gene expression by interleukin 2: immediate-response genes include the proto-oncogene c-myb.
Article in Molecular and cellular biology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 34 citations in OpenAlex.
- MicroRNA miR-150 is involved in Vα14 invariant NKT cell development and function.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- c-Myb transcription is activated by protein kinase B (PKB) following interleukin 2 stimulation of Tcells and is required for PKB-mediated protection from apoptosis.Molecular and cellular biology · 2001Article
- c-Myb and Ets proteins synergize to overcome transcriptional repression by ZEB.The EMBO journal · 1997Article
- Identification of an inducible regulator of c-myb expression during T-cell activation.Molecular and cellular biology · 1996Article
- Regulation of the T-cell receptor delta enhancer by functional cooperation between c-Myb and core-binding factors.Molecular and cellular biology · 1994Article
- Expression of the CD4 gene requires a Myb transcription factor.Molecular and cellular biology · 1992Article
- Article
- Functional analysis of c-Myb protein in T-lymphocytic cell lines shows that it trans-activates the c-myc promoter.Molecular and cellular biology · 1990Article
- Differential binding of nuclear factors to the intron 1 sequences containing the transcriptional pause site correlates with c-myb expression.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Human immunodeficiency virus infection of monoblastoid cells: cellular differentiation determines the pattern of virus replication.Journal of virology · 1988Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Antigen-stimulated human T lymphocytes must bind the immunoregulatory hormone interleukin 2 (IL-2) if they are to transit from the G1 to the S phase of the cell cycle. Indirect methods, such as the measurement of thymidine uptake rates, were previously the only means available for exploring the mechanism of action of IL-2. Several cDNA clones have been isolated which are expressed subsequent to IL-2 binding, and the expression of two of these genes. Tact52 and Tact75, is regulated directly at the level of transcription; expression of the proto-oncogene c-myb is also regulated directly by IL-2 binding. These genes thus constitute a set which is coordinately regulated in the course of the transition from G1 to S phase of human T lymphocytes, and their expression depends on IL-2 binding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.