ArticleJACC. Heart failure2019
Association of Urine Albumin Excretion With Incident Heart Failure Hospitalization in Community-Dwelling Adults.
Article in JACC. Heart failure, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Kidney Disease and Heart Failure: Recent Advances and Current Challenges: Conclusions From a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.JACC. Heart failure · 2026Guideline
- Association of Kidney Tubule Dysfunction and Injury Biomarkers With Long-term Risk of Acute Kidney Injury During Acute Congestive Heart Failure Hospitalizations.Kidney medicine · 2026Article
- Cardiovascular Disease Incidence and Risk Factor Contributions in Adults Aged 45 to 59 Years With Low 10-Year and High 30-Year Risk: Findings From REGARDS.Circulation. Population health and outcomes · 2026Article
- Combined impact of microalbuminuria and obesity on cardiovascular outcomes in hospitalized heart failure patients: a cohort study.BMC cardiovascular disorders · 2026Observational
- Effect of GDMT Optimization on KDIGO Risk Categories in HFrEF: Analysis of the VIENNA-HF Registry.JACC. Advances · 2026Article
- Cardiovascular Events in US Adults Aged ≥80 Years: Incidence, Risk Factors, and Outcomes.Circulation. Population health and outcomes · 2026Article
- The Synergistic Treatment of Heart and Kidney Disease.Deutsches Arzteblatt international · 2026Review
- Albuminuria in Cardiovascular, Kidney, and Metabolic Disorders: A State-of-the-Art Review.Circulation · 2025Review
- Congestion as a crucial factor determining albuminuria in patients with cardiorenal disease.Clinical kidney journal · 2024Article
- Neighborhood Disadvantage and Risk of Heart Failure: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study.Circulation. Cardiovascular quality and outcomes · 2024Article
- Association between serum albumin to serum creatinine ratio and mortality risk in patients with heart failure.Clinical and translational science · 2023Article
- Patient Awareness of Their Heart Failure Diagnosis and Its Implications for Epidemiologic Studies and Clinical Care.The American journal of cardiology · 2023Article
- Chronic Kidney Disease, Heart Failure, and Adverse Cardiac Remodeling in Older Adults: The ARIC Study.JACC. Heart failure · 2023Article
- Association of Perceived Stress With Incident Heart Failure.Journal of cardiac failure · 2022Article
- Association of Transthyretin Val122Ile Variant With Incident Heart Failure Among Black Individuals.JAMA · 2022Article
- Microalbuminuria and its Prognostic Significance in Patients with Acute Heart Failure with Preserved, Mid-Range, and Reduced Ejection Fraction.Arquivos brasileiros de cardiologia · 2022Article
- Biomarkers in Heart Failure with Preserved Ejection Fraction.Cardiac failure review · 2022Review
- Observational
- The Dietary Approaches to Stop Hypertension (DASH) Diet Pattern and Incident Heart Failure.Journal of cardiac failure · 2021Article
- Risk-Based Approach for the Prediction and Prevention of Heart Failure.Circulation. Heart failure · 2021Review
Corrections and comments
- Commented on by
- Erratum issuedCorrection.2019
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesThis study examined the association between urinary albumin excretion and incident heart failure (HF) hospitalization.
backgroundExcess urinary albumin excretion is more strongly associated with incident stroke and coronary heart disease risk in black than in white individuals. Whether similar associations extend to HF is unclear.
methodsThis study examined the associations between the urinary albumin-to-creatinine ratio (ACR) and incident hospitalization for HF overall in 24,433 REGARDS (Reasons for Geographic and Racial Differences in Stroke) study participants free of suspected HF at baseline; findings were stratified by race and HF subtype (preserved vs. reduced ejection fraction). Models were adjusted for sociodemographic, clinical, and laboratory variables including estimated glomerular filtration rate, and multiple imputation was used to account for missing covariate data.
resultsAfter a median follow-up of 9.2 years, 881 incident HF events (332 preserved ejection fraction, 447 reduced ejection fraction, 102 unspecified) were observed. Compared to the lowest ACR category (<10 mg/g), the risk of incident HF increased with increasing ACR categories (10 to 29 mg/g hazard ratio [HR]: 1.49; 95% confidence interval [CI]: 1.26 to 1.78; 30 to 300 mg/g HR: 2.32; 95% CI: 1.93 to 2.78; >300 mg/g HR: 4.42; 95% CI: 3.36 to 5.83) in the fully adjusted model. Results did not differ by race. The magnitude of the association between ACR and HF with preserved ejection fraction was greater than with HF with reduced ejection fraction (HR comparing highest vs. lowest ACR category: 6.20; 95% CI: 4.15 to 9.26 vs. HR: 4.37; 95% CI: 3.00 to 6.25, respectively; p = 0.05).
conclusionsHigher ACR was associated with greater risk of incident HF hospitalization in community-dwelling black and white adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.