ReviewJACC. Heart failure2019
Medical Management of Heart Failure With Reduced Ejection Fraction in Patients With Advanced Renal Disease.
Review in JACC. Heart failure, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Kidney Disease and Heart Failure: Recent Advances and Current Challenges: Conclusions From a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.JACC. Heart failure · 2026Guideline
- Systematic Review on the Management of Diuretic Resistance in Acute Heart Failure across the Spectrum of Kidney Disease.Cardiorenal medicine · 2025Pooled it
- Remote Hemodynamic-Guided Therapy of Patients With Recurrent Heart Failure Following Cardiac Resynchronization Therapy.Journal of the American Heart Association · 2021Trial
- Non-Cardiac Comorbidities in Acute Heart Failure: Phenotype-Specific Insights from Sub-Saharan Africa.Journal of clinical medicine · 2026Article
- Renin Angiotensin Inhibition and Lower Risk of Kidney Failure in Patients with Heart Failure.The American journal of medicine · 2025Article
- Probiotics restore enteric HDL3 secretion and improve prognosis in patients with end-stage renal disease.iMeta · 2025Article
- Defining the predictors for post renal transplant left ventricular dysfunction in end-stage renal disease patients.Physiological reports · 2025Article
- The Early Pharmacological Strategy with Inodilator, bEta-blockers, Mineralocorticoid Receptor Antagonists, Sodium-glucose coTransporter-2 Inhibitors and Angiotensin Receptor-neprylisin Inhibitors in Acute Heart Failure (PENTA-HF).Current vascular pharmacology · 2025Observational
- Impact of discharge checklist on guideline-directed medical therapy and mid-term prognosis in heart failure.The Korean journal of internal medicine · 2024Observational
- Evolutions in Combined Heart-Kidney Transplant.Current heart failure reports · 2024Review
- Do Implantable Cardioverter-Defibrillators Prevent Sudden Cardiac Death in End-Stage Renal Disease Patients on Dialysis?Journal of clinical medicine · 2024Review
- Angiotensin Receptor-Neprilysin Inhibitor in Heart Failure Patients With Renal Dysfunction.Cardiovascular therapeutics · 2024Review
- Renin-Angiotensin Inhibition and Outcomes in HFrEF and Advanced Kidney Disease.The American journal of medicine · 2023Article
- Review
- Multimorbidity, guideline-directed medical therapies, and associated outcomes among hospitalized heart failure patients.ESC heart failure · 2022Article
- The unmet need of evidence-based therapy for patients with advanced chronic kidney disease and heart failure: Position paper from the Cardiorenal Working Groups of the Spanish Society of Nephrology and the Spanish Society of Cardiology.Clinical kidney journal · 2022Article
- Tipping the scale toward a more accurate and equitable assessment of heart failure with reduced ejection fraction pharmacotherapy eligibility: a call to incorporate cystatin C in estimating glomerular filtration rate.European journal of heart failure · 2022Article
- Evidence-Based Medical Therapy in Patients With Heart Failure With Reduced Ejection Fraction and Chronic Kidney Disease.Circulation · 2022Review
- Article
- Kidney Function and Outcomes in Patients Hospitalized With Heart Failure.Journal of the American College of Cardiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Large randomized clinical trials (RCT) supporting guidelines for the management of heart failure with reduced ejection fraction (HFrEF) have typically excluded patients with advanced chronic kidney disease (CKD). Patients with concomitant advanced CKD and HFrEF experience poor cardiovascular outcomes and mortality relative to either disease in isolation and have been shown to consistently receive lower rates of HFrEF guideline-directed medical therapy (GDMT). This review evaluated recent evidence for the use of GDMT in patients with HFrEF and advanced CKD approaching dialysis from RCTs and observational cohorts. The authors also discuss the limitations and challenges inherent in the evidence for GDMT in this population, and offer guidance to clinicians for proper clinical use and future research directions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.