ArticleCritical care (London, England)2019
Influenza and associated co-infections in critically ill immunosuppressed patients.
Article in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Interpreting viral severe acute respiratory infection in critically ill immunocompromised patients: phenotype, co-infections, and severity.Critical care (London, England) · 2026Article
- Clinical-epidemiological predictors of phlebitis associated with peripheral intravenous catheters in Spanish hospitals: results of a national cohort study.International journal of nursing studies advances · 2025Article
- Article
- Clinical characteristics analysis and prediction model construction for pediatric influenza virus pneumonia complicated by bacterial infection.Translational pediatrics · 2025Article
- A Machine Learning Approach to Determine Risk Factors for Respiratory Bacterial/Fungal Coinfection in Critically Ill Patients with Influenza and SARS-CoV-2 Infection: A Spanish Perspective.Antibiotics (Basel, Switzerland) · 2024Article
- Clinical significance of lower respiratory tract culture within 48 h of admission in patients with viral pneumonia: an observational study.BMC pulmonary medicine · 2024Observational
- Viral co-detection of influenza virus and other respiratory viruses in hospitalized Brazilian patients during the first three years of the coronavirus disease (COVID)-19 pandemic: an epidemiological profile.Frontiers in microbiology · 2024Article
- Clinical significance of human metapneumovirus detection in critically ill adults with lower respiratory tract infections.Annals of intensive care · 2023Article
- Clinical features and outcome of influenza pneumonia in critically-ill immunocompromised patients.Medicine · 2022Observational
- Respiratory Syncytial Virus Provides Protection against a Subsequent Influenza A Virus Infection.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Article
- Potential therapeutic effects of interleukin-35 on the differentiation of naïve T cells into HeliosMolecular immunology · 2021Article
- Acute respiratory failure in immunocompromised patients: outcome and clinical features according to neutropenia status.Annals of intensive care · 2020Article
- Review of influenza-associated pulmonary aspergillosis in ICU patients and proposal for a case definition: an expert opinion.Intensive care medicine · 2020Article
- Article
- Focus on infection.Intensive care medicine · 2020Article
- Severe flu management: a point of view.Intensive care medicine · 2020Review
- Influenza Infections and Emergent Viral Infections in Intensive Care Unit.Seminars in respiratory and critical care medicine · 2019Review
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41 authors.
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Abstract
backgroundIt is unclear whether influenza infection and associated co-infection are associated with patient-important outcomes in critically ill immunocompromised patients with acute respiratory failure.
methodsPreplanned secondary analysis of EFRAIM, a prospective cohort study of 68 hospitals in 16 countries. We included 1611 patients aged 18 years or older with non-AIDS-related immunocompromise, who were admitted to the ICU with acute hypoxemic respiratory failure. The main exposure of interest was influenza infection status. The primary outcome of interest was all-cause hospital mortality, and secondary outcomes ICU length of stay (LOS) and 90-day mortality.
resultsInfluenza infection status was categorized into four groups: patients with influenza alone (n = 95, 5.8%), patients with influenza plus pulmonary co-infection (n = 58, 3.6%), patients with non-influenza pulmonary infection (n = 820, 50.9%), and patients without pulmonary infection (n = 638, 39.6%). Influenza infection status was associated with a requirement for intubation and with LOS in ICU (P < 0.001). Patients with influenza plus co-infection had the highest rates of intubation and longest ICU LOS. On crude analysis, influenza infection status was associated with ICU mortality (P < 0.001) but not hospital mortality (P = 0.09). Patients with influenza plus co-infection and patients with non-influenza infection alone had similar ICU mortality (41% and 37% respectively) that was higher than patients with influenza alone or those without infection (33% and 26% respectively). A propensity score-matched analysis did not show a difference in hospital mortality attributable to influenza infection (OR = 1.01, 95%CI 0.90-1.13, P = 0.85). Age, severity scores, ARDS, and performance status were all associated with ICU, hospital, and 90-day mortality.
conclusionsCategory of infectious etiology of respiratory failure (influenza, non-influenza, influenza plus co-infection, and non-infectious) was associated with ICU but not hospital mortality. In a propensity score-matched analysis, influenza infection was not associated with the primary outcome of hospital mortality. Overall, influenza infection alone may not be an independent risk factor for hospital mortality in immunosuppressed patients.
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