ArticleParasites & vectors2019
Old World cutaneous leishmaniasis treatment response varies depending on parasite species, geographical location and development of secondary infection.
Article in Parasites & vectors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Role of Microbiome and Bacterial Biofilms in the Pathogenesis of Cutaneous Leishmaniasis.Acta parasitologica · 2026Review
- In vitro and in vivo evaluation of the leishmanicidal and cytotoxic activities of chitosan and chitosan-amphotericin B.AMB Express · 2025Article
- Antiparasitic and Antifungal Activities of Cetyl-Maritima, a NewAntibiotics (Basel, Switzerland) · 2025Article
- Antiparasitic Activities of Acyl Hydrazones from Cinnamaldehydes and Structurally Related Fragrances.Antibiotics (Basel, Switzerland) · 2024Article
- First report of Leishmania tropica in domestic and wild animal hosts in hyperendemic areas of human cutaneous leishmaniasis in western Yemen: a neglected tropical disease needing One Health approach.Parasitology research · 2024Article
- Potential Effects of Essential Oil fromMicroorganisms · 2024Article
- Article
- Seroprevalence of Toscana and sandfly fever Sicilian viruses in humans and livestock animals from western Saudi Arabia.One health (Amsterdam, Netherlands) · 2023Article
- Histological findings associated with treatment response in cutaneous leishmaniasis: a clinicopathological correlation study.International journal of dermatology · 2023Article
- Leishmania donovani persistence and circulation causing cutaneous leishmaniasis in unusual-foci of Nepal.Scientific reports · 2023Article
- Molecular Characterization ofPathogens (Basel, Switzerland) · 2022Article
- Genotypic and phylogenic analyses of cutaneous leishmaniasis in Al Ahsa, Eastern Saudi Arabia during the coronavirus disease 2019 pandemic: First cases of Leishmania tropica with the predominance of Leishmania major.Scientific reports · 2022Article
- Article
- First Evidence from Sri Lanka for Subphenotypic Diversity withinBioMed research international · 2021Article
- Recent evolution on synthesis strategies and anti-leishmanial activity of β-carboline derivatives - An update.Heliyon · 2020Review
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn the Kingdom of Saudi Arabia (KSA), Leishmania major and L. tropica are the main causative agents of Old World cutaneous leishmaniasis (CL). The national CL treatment regimen consists of topical 1% clotrimazole/2% fusidic acid cream followed by 1-2 courses of intralesional sodium stibogluconate (SSG); however, treatment efficacy is highly variable and the reasons for this are not well understood. In this study, we present a complete epidemiological map of CL and determined the efficacy of the standard CL treatment regime in several endemic regions of KSA.
resultsOverall, three quarters of patients in all CL-endemic areas studied responded satisfactorily to the current treatment regime, with the remaining requiring only an extra course of SSG. The majority of unresponsive cases were infected with L. tropica. Furthermore, the development of secondary infections (SI) around or within the CL lesion significantly favoured the treatment response of L. major patients but had no effect on L. tropica cases.
conclusionsThe response of CL patients to a national treatment protocol appears to depend on several factors, including Leishmania parasite species, geographical location and occurrences of SI. Our findings suggest there is a need to implement alternative CL treatment protocols based on these parameters.
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