Evidence map›Paper›PMID 31046806›Full record

Trial reportJournal of cardiothoracic surgery2019

SUPERIOR SVG: no touch saphenous harvesting to improve patency following coronary bypass grafting (a multi-Centre randomized control trial, NCT01047449).

Saswata Deb, Steve K Singh, Domingos de Souza, Michael W A Chu, Richard Whitlock, Steven R Meyer, Subodh Verma, Anders Jeppsson, Ayman Al-Saleh, Katheryn Brady and 7 more

2 registry-linked trialsOpen access · goldAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cardiothoracic surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 54 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 7 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01047449 nacompletednot on this map

Surgical and Pharmacological Novel Interventions to Improve Overall Results of Saphenous Vein Graft Patency in Coronary Artery Bypass Grafting Surgery: An International Multi-Center Randomized Controlled Clinical Trial

TypeinterventionalSponsorSunnybrook Health Sciences CentreRan2011 to 2017Enrolled250ConditionsCoronary Artery DiseaseArmsNo-touch SVG harvest vs conventional SVG harvest technique, Fish oil supplementation vs placebo
NCT06496321 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Morbidity of Conventional and No-touch Saphenectomy in Coronary Artery Bypass Grafting, a Randomized Non-inferiority Clinical Trial

TypeinterventionalSponsorInstituto Nacional de Cirugia Cardiaca, UruguayRan2024 to 2025Enrolled52ConditionsSaphenectomy, No Touch, Coronary Artery Disease, Cardiovascular DiseasesArmsConventional Saphenous vein harvest, No touch Saphenous vein harvest
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 7 syntheses or guidelines pooled it, 114 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
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  5. Pooled it
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  7. Pooled it
  8. Trial
  9. Trial
  10. Impact of Graft Velocity on Saphenous Vein Graft Atherosclerosis after Coronary Artery Bypass Grafting.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2024
    Trial
  11. Trial
  12. Stable Hemodynamics within "No-Touch" Saphenous Vein Graft.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2020
    Trial
  13. Article
  14. Review
  15. Article
  16. Great Saphenous Vein Lumen: Intimal Openings.Brazilian journal of cardiovascular surgery · 2026
    Review
  17. Article
  18. Review
  19. Observational
  20. Role of Perivascular Adipose Tissue in Vein Remodeling.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 3 countries.

Saswata DebSunnybrook Health Sciences Centre, Institute of Health Policy, Management and Evaluation, University of Toronto, 2075 Bayview Ave., Room H405, Toronto, ON, M4N 3M5, Canada.
Steve K SinghBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Domingos de SouzaDepartment of Cardiothoracic and Vascular Surgery, Orebro University, Orebro, Sweden.
Michael W A ChuDepartment of Surgery, Western University, London Health Sciences Centre, London, Canada.
Richard WhitlockPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada.
Steven R MeyerMazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada.
Subodh VermaSt. Michael's Hospital, Toronto, Canada.
Anders JeppssonDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Ayman Al-SalehMcMaster University, Hamilton, Canada.
Katheryn BradyPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada.
Purnima Rao-MelaciniPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada.
Emilie P Belley-CotePopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada.
Derrick Y TamSunnybrook Health Sciences Centre, Institute of Health Policy, Management and Evaluation, University of Toronto, 2075 Bayview Ave., Room H405, Toronto, ON, M4N 3M5, Canada.
P J DevereauxPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada.
Richard J NovickUniversity of Calgary and Foothills Medical Centre, Calgary, Canada.
Stephen E FremesSunnybrook Health Sciences Centre, Institute of Health Policy, Management and Evaluation, University of Toronto, 2075 Bayview Ave., Room H405, Toronto, ON, M4N 3M5, Canada. stephen.fremes@sunnybrook.ca.
SUPERIOR SVG Study Investigators
Sunnybrook Health Science Centre · CAPopulation Health Research Institute · CABrigham and Women's Hospital · USSt. Michael's Hospital · CAWestern University · CAUniversity of Alberta · CAUniversity of Calgary · CAUniversity of Gothenburg · SE

Funding

CIHR CANNeCTINHeart and Stroke Foundation of Canada 7092
6 · The paper itself

Abstract

backgroundSingle centre studies support No Touch (NT) saphenous vein graft (SVG) harvesting technique. The primary objective of the SUPERIOR SVG study was to determine whether NT versus conventional (CON) SVG harvesting was associated with improved SVG patency 1 year after coronary artery bypass grafting surgery (CABG).

methodsAdults undergoing isolated CABG with at least 1 SVG were eligible. CT angiography was performed 1-year post CABG. Leg adverse events were assessed with a questionnaire. A systematic review was performed for published NT graft patency studies and results aggregated including the SUPERIOR study results.

resultsTwo hundred and-fifty patients were randomized across 12-centres (NT 127 versus CON 123 patients). The primary outcome (study SVG occlusion or cardiovascular (CV) death) was not significantly different in NT versus CON (NT: 7/127 (5.5%), CON 13/123 (10.6%), p = 0.15). Similarly, the proportion of study SVGs with significant stenosis or total occlusion was not significantly different between groups (NT: 8/102 (7.8%), CON: 16/107 (15.0%), p = 0.11). Vein harvest site infection was more common in the NT patients 1 month postoperatively (23.3% vs 9.5%, p < 0.01). Including this study's results, in a meta-analysis, NT was associated with a significant reduction in SVG occlusion, Odds Ratio 0.49, 95% Confidence Interval 0.29-0.82, p = 0.007 in 3 randomized and 1 observational study at 1 year postoperatively.

conclusionsThe NT technique was not associated with improved patency of SVGs at 1-year following CABG while early vein harvest infection was increased. The aggregated data is supportive of an important reduction of SVG occlusion at 1 year with NT harvesting.

trial registrationNCT01047449 .

Indexed as

AdultCoronary Artery BypassFemaleHumansMaleSaphenous VeinTissue and Organ HarvestingVascular PatencyConventional open saphenous vein graft harvestingCoronary artery bypass grafting surgeryEndoscopic saphenous vein graft harvestingGraft patencyMajor adverse cardiac and cerebrovascular outcomesMulti-centred randomized controlled trialNo touch atraumatic saphenous vein graft harvesting

Identifiers

PMID31046806
PMCPMC6498551
OpenAlexW2942651914

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.