Evidence map›Paper›PMID 31046760›Full record

ArticleBMC medical informatics and decision making2019

Quantile-based fecal hemoglobin concentration for assessing colorectal neoplasms with 1,263,717 Taiwanese screenees.

Szu-Min Peng, Han-Mo Chiu, Hsiao-Hsuan Jen, Chen-Yang Hsu, Sam Li-Sheng Chen, Sherry Yueh-Hsia Chiu, Amy Ming-Fang Yen, Jean Ching-Yuan Fann, Yi-Chia Lee, Hsiu-Hsi Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical informatics and decision making, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Szu-Min PengInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Room 533, 5F. No. 17, Hsu Chow Road, Zhongzheng District, Taipei, 100, Taiwan.
Han-Mo ChiuDepartments of Internal Medicine, National Taiwan University Hospital, No.7, Chung-Shan South Road, Zhongzheng District, Taipei, 100, Taiwan.
Hsiao-Hsuan JenInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Room 533, 5F. No. 17, Hsu Chow Road, Zhongzheng District, Taipei, 100, Taiwan.
Chen-Yang HsuInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Room 533, 5F. No. 17, Hsu Chow Road, Zhongzheng District, Taipei, 100, Taiwan.
Sam Li-Sheng ChenSchool of Oral Hygiene, College of Oral Medicine, Taipei Medical University, No. 250, Wu-Hsing Street, Sinyi District, Taipei, 110, Taiwan.
Sherry Yueh-Hsia ChiuDepartment of Health Care Management and Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan.
Amy Ming-Fang YenSchool of Oral Hygiene, College of Oral Medicine, Taipei Medical University, No. 250, Wu-Hsing Street, Sinyi District, Taipei, 110, Taiwan.
Jean Ching-Yuan FannDepartment of Health Industry Management, School of Healthcare Management, Kainan University, No.1, Kainan Road, Luzhu District, Taoyuan, 338, Taiwan.
Yi-Chia LeeDepartments of Internal Medicine, National Taiwan University Hospital, No.7, Chung-Shan South Road, Zhongzheng District, Taipei, 100, Taiwan.
Hsiu-Hsi ChenInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Room 533, 5F. No. 17, Hsu Chow Road, Zhongzheng District, Taipei, 100, Taiwan. chenlin@ntu.edu.tw.ORCID 0000-0002-5799-6705
National Taiwan University · TWNational Taiwan University Hospital · TWTaipei Medical University · TWChang Gung University · TWKainan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough fecal hemoglobin concentration (f-Hb) was highly associated with the risk of colorectal neoplasms, current studies on this subject are hampered by skewedness of the data and the ordinal property of f-Hb has not been well studied yet. Our aim was to develop a quantile-based method to estimate adjusted percentiles (median) of fecal hemoglobin concentration and their derived prediction for the risk of multistage outcomes of colorectal disease.

methodsWe used a 6-year follow-up cohort of Taiwanese nationwide colorectal screening program with fecal immunochemical testing (FIT) to obtain fecal hemoglobin concentration and applied accelerated failure time multi-variable analyses to make the comparison of adjusted median and other percentitles of fecal hemoglobin across four categories of colorectal carcinogenesis. We then predicted the risk of colorectal neoplasms on the basis of the corresponding percentile values by using accelerated failure time model with Bayesian inversion method.

resultsThe adjusted median fecal hemoglobin concentration of nonadvanced adenoma, advanced adenoma, and colorectal cancer were 57, 82, and 163 μg/g feces as opposed to 0 μg/g feces for the normal group. At 90 μg/g of f-Hb, the highly suspected cut-off for colorectal disease, the risks were 17% for non-advanced adenoma, 6% for advanced adenoma, and 9% for CRC. Life-time risks of each colorectal neoplasm were derived by percentiles of fecal hemoglobin concentration.

conclusionCovariate-adjusted risk stratification for multistage outcomes of colorectal neoplasia were provided by using the quantiles of fecal hemoglobin concentration, yielding the estimated life-time risks of 25th to 75th quantitles, ranging from 0.5 to 44% for colorectal cancer, 0.2 to 46% for non-advanced adenoma, and 0.1 to 20% for advanced adenoma.

Indexed as

Early Detection of CancerOccult BloodAdenomaAgedBayes TheoremCohort StudiesColonoscopyColorectal NeoplasmsFecesFemaleHemoglobinsHumansMaleMiddle AgedPredictive Value of TestsTaiwanHemoglobinsColorectal cancerFecal hemoglobinScreening

Identifiers

PMID31046760
PMCPMC6498550
OpenAlexW2947702865

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.