ArticleBMC gastroenterology2019
The impact of diagnosis on health-related quality of life in people with coeliac disease: a UK population-based longitudinal perspective.
Article in BMC gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Defining the optimum strategy for identifying adults and children with coeliac disease: systematic review and economic modelling.Health technology assessment (Winchester, England) · 2022Pooled it
- Quality of Life and Societal Costs Related to Celiac Disease Before and After Diagnosis.Clinical and translational gastroenterology · 2026Article
- Psychometric testing of the ICECAP-A in patients with coeliac disease: a comparative analysis with EQ-5D-5L.Health and quality of life outcomes · 2025Article
- The added value of the cognition, dining, gastrointestinal problems, sleep and tiredness bolt-on dimensions to the EQ-5D-5L in patients with coeliac disease.The European journal of health economics : HEPAC : health economics in prevention and care · 2025Article
- Physical and psychological symptoms and survey importance in celiac disease.World journal of gastrointestinal endoscopy · 2024Article
- Article
- Associations between Celiac Disease, Extra-Gastrointestinal Manifestations, and Gluten-Free Diet: A Narrative Overview.Nutrients · 2024Review
- Navigating coeliac disease diagnosis in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2024Article
- The financial impact on people with coeliac disease of withdrawing gluten-free food from prescriptions in England: findings from a cross-sectional survey.BMC health services research · 2024Article
- Celiac Disease in Moroccan Children: Diagnostic Characteristics and Determinants of Diagnosis Delay.Cureus · 2023Article
- Health utilities and willingness to pay in adult patients with coeliac disease in Hungary.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- The COVID-19 pandemic and health-related quality of life across 13 high- and low-middle-income countries: A cross-sectional analysis.PLoS medicine · 2023Article
- Compliance with Gluten Free Diet Is Associated with Better Quality of Life in Celiac Disease.Nutrients · 2022Article
- Impaired Quality of Life in Patients with Autoimmune Atrophic Gastritis.Digestive diseases and sciences · 2021Observational
- The influence of a gluten-free diet on health-related quality of life in individuals with celiac disease.BMC gastroenterology · 2021Article
- The impact of symptoms on quality of life before and after diagnosis of coeliac disease: the results from a Polish population survey and comparison with the results from the United Kingdom.BMC gastroenterology · 2021Article
- Do gastroenterologists have medical inertia towards coeliac disease? A UK multicentre secondary care study.BMJ open gastroenterology · 2021Article
- Health related QoL in celiac disease patients in Slovenia.Health and quality of life outcomes · 2020Article
- Celiac disease and Sjögren's syndrome: A case report and review of literature.World journal of clinical cases · 2020Article
- Withdrawing gluten-free food from prescriptions in England: a mixed-methods study to examine the impact of policy changes on quality of life.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2020Article
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Abstract
backgroundBefore diagnosis, people with coeliac disease suffer reduced quality of life, which improves substantially after the disease has been diagnosed. Delayed diagnosis is common. The aim of this study was to assess changes over time in prevalence of coeliac disease symptoms/associated medical conditions, time to diagnosis, quality of life and its determinants before and after diagnosis in the United Kingdom.
methodsA postal questionnaire was designed in 2015 and sent to 4000 individuals with diagnosed coeliac disease, requesting information on respondents' socio-demographic and clinical characteristics, and their quality of life pre- and post-diagnosis using the EQ-5D instrument. Data were analysed and compared with results from a survey conducted in 2006 using descriptive analyses, univariate and multivariable regression methods.
resultsThe survey response rate was 40%. Sixty-five percent of respondents reported at least 4 symptoms pre-diagnosis, a significant reduction by 13 percentage points (95% CI: -16.9, - 9.4; p-value: < 0.001) compared to 2006. Pre-diagnosis mean duration of symptoms was 12.8 years (SD: 15.3), a non-significant reduction of 0.6 years (95% CI: -2, 0.8; p-value: 0.426) compared to 2006. There was a significant improvement of 0.20 (95% CI: 0.18, 0.22; p-value: < 0.001) in quality of life from pre- (0.65) to post-diagnosis (0.85). Pre-diagnosis values were significantly higher by 0.09 (95% CI: 0.06, 0.12; p-value: < 0.001) than in 2006. Number of symptoms and low income were associated with decreased quality of life.
conclusionsUndiagnosed coeliac disease is associated with a substantial decrement in quality of life. Time to diagnosis has not significantly shortened over the decade 2006-2015, but symptoms are less severe when diagnosis occurs. Harmonising clinical guidelines for intensified active case finding will help improve quality of life of people with coeliac disease.
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