ArticleInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group2019
Tissue-mimicking thermochromic phantom for characterization of HIFU devices and applications.
Article in International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Hyperthermia-targeted rectal delivery of thermosensitive liposomal doxorubicin via intra-arterial and intravenous administration.Frontiers in pharmacology · 2026Article
- Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Review
- Assessment of thermochromic phantoms for characterizing microwave ablation devices.Medical physics · 2024Article
- Thermochromic Polymer Nanocomposites for the Heat Detection System: Recent Progress on Properties, Applications, and Challenges.Polymers · 2024Review
- Simple, inexpensive, and ergonomic phantom for quality assurance control of MRI guided Focused Ultrasound systems.Journal of ultrasound · 2023Article
- Morphometric characterization and temporal temperature measurements during hepatic microwave ablation in swine.PloS one · 2023Article
- Development of Tough Hydrogel Phantoms to Mimic Fibrous Tissue for Focused Ultrasound Therapies.Ultrasound in medicine & biology · 2022Article
- Robust and durable aberrative and absorptive phantom for therapeutic ultrasound applications.The Journal of the Acoustical Society of America · 2022Article
- MR relaxation times of agar-based tissue-mimicking phantoms.Journal of applied clinical medical physics · 2022Article
- Single-cell RNA sequencing reveals the mechanism of sonodynamic therapy combined with a RAS inhibitor in the setting of hepatocellular carcinoma.Journal of nanobiotechnology · 2021Article
- Thermochromic Tissue Phantoms for Evaluating Temperature Distribution in Simulated Clinical Applications of Pulsed Electric Field Therapies.Bioelectricity · 2020Article
- Contactless Thermometry by MRI and MRS: Advanced Methods for Thermotherapy and Biomaterials.iScience · 2020Review
- High-Intensity Focused Ultrasound (HIFU) Triggers Immune Sensitization of Refractory Murine Neuroblastoma to Checkpoint Inhibitor Therapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020Article
- High-quality Agar and Polyacrylamide Tumor-mimicking Phantom Models for Magnetic Resonance-guided Focused Ultrasound Applications.Journal of medical ultrasoundArticle
- Utilizing an Agar/Silica Phantom for Magnetic Resonance Imaging-guided Focused Ultrasound Evaluation: Lesion Formation, Magnetic Resonance Imaging Manifestation, and Comparison with Porcine Tissue.Journal of medical ultrasoundArticle
- Estimation of the Proton Resonance Frequency Coefficient in Agar-based Phantoms.Journal of medical physicsArticle
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6 authors.
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Abstract
purposeTissue-mimicking phantoms (TMPs) are synthetic materials designed to replicate properties of biological tissues. There is a need to quantify temperature changes following ultrasound or magnetic resonance imaging-guided high intensity focused ultrasound (MR-HIFU). This work describes development, characterization and evaluation of tissue-mimicking thermochromic phantom (TMTCP) for direct visualization and quantification of HIFU heating. The objectives were to (1) develop an MR-imageable, HIFU-compatible TMTCP that reports absolute temperatures, (2) characterize TMTCP physical properties and (3) examine TMTCP color change after HIFU. METHODS AND MATERIALS: A TMTCP was prepared to contain thermochromic ink, silicon dioxide and bovine serum albumin (BSA) and its properties were quantified. A clinical MRI-guided and a preclinical US-guided HIFU system were used to perform sonications in TMTCP. MRI thermometry was performed during HIFU, followed by T2-weighted MRI post-HIFU. Locations of color and signal intensity change were compared to the sonication plan and to MRI temperature maps.
resultsTMTCP properties were comparable to those in human soft tissues. Upon heating, the TMTCP exhibited an incremental but permanent color change for temperatures between 45 and 70 °C. For HIFU sonications the TMTCP revealed spatially sharp regions of color change at the target locations, correlating with MRI thermometry and hypointense regions on T2-weighted MRI. TMTCP-based assessment of various HIFU applications was also demonstrated.
conclusionsWe developed a novel MR-imageable and HIFU-compatible TMTCP to characterize HIFU heating without MRI or thermocouples. The HIFU-optimized TMTCP reports absolute temperatures and ablation zone geometry with high spatial resolution. Consequently, the TMTCP can be used to evaluate HIFU heating and may provide an in vitro tool for peak temperature assessment, and reduce preclinical in vivo requirements for clinical translation.
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