Evidence map›Paper›PMID 31046479›Full record

ReviewExpert opinion on drug delivery2019

An update on the contribution of hot-melt extrusion technology to novel drug delivery in the twenty-first century: part II.

Sandeep Sarabu, Suresh Bandari, Venkata Raman Kallakunta, Roshan Tiwari, Hemlata Patil, Michael A Repka

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Expert opinion on drug delivery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
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  16. Article
  17. Review
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  19. Quality-by-design in hot melt extrusion based amorphous solid dispersions: An industrial perspective on product development.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sandeep Sarabua Department of Pharmaceutics and Drug Delivery , The University of Mississippi, University , MS , USA.
Suresh Bandaria Department of Pharmaceutics and Drug Delivery , The University of Mississippi, University , MS , USA.
Venkata Raman Kallakuntaa Department of Pharmaceutics and Drug Delivery , The University of Mississippi, University , MS , USA.
Roshan Tiwaria Department of Pharmaceutics and Drug Delivery , The University of Mississippi, University , MS , USA.
Hemlata Patila Department of Pharmaceutics and Drug Delivery , The University of Mississippi, University , MS , USA.
Michael A Repkaa Department of Pharmaceutics and Drug Delivery , The University of Mississippi, University , MS , USA.

Funding

Center of Research Excellence in Natural Products Neuroscience (CORE-NPN)P20GM104932 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI MAJUMDAR, SOUMYAJIT · 2012 to 2016
$10.0M
NIGMS NIH HHS P20 GM104932
6 · The paper itself

Abstract

introductionInterest in hot-melt extrusion (HME) technology for novel applications is growing day by day, which is evident from several hundred publications within the last 5 years. HME is a cost-effective, solvent free, 'green' technology utilized for various formulations with low investment costs compared to conventional technologies. HME has also earned the attention of the pharmaceutical industry by the transformation of this technology for application in continuous manufacturing. AREAS COVERED: Part II of the review focuses on various novel opportunities or innovations of HME such as multiple component systems (co-crystals, co-amorphous systems and salts), twin-screw granulation, semi-solids, co-extrusion, abuse deterrent formulations, solid self-emulsifying drug delivery systems, chronotherapeutic drug delivery systems, and miscellaneous applications. EXPERT OPINION: HME is being investigated as an alternative technology for preparation of multicomponent systems such as co-crystals and co-amorphous techniques. Twin-screw granulation has gained increased interest in preparation of granules via twin-screw melt granulation or twin-screw

Indexed as

Hot Melt Extrusion TechnologyDrug CompoundingDrug IndustryHot TemperaturePharmaceutical PreparationsTechnology, PharmaceuticalPharmaceutical PreparationsAbuse deterrent formulationsco-extrusionhot melt extrusionpharmaceutical co-crystalssemi-solid formulationstwin-screw granulation

Identifiers

PMID31046479
PMCPMC6568324

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.