Evidence map›Paper›PMID 31046296›Full record

ArticleOrganic letters2019

Ni-Catalyzed Cross-Electrophile Coupling for the Synthesis of Skipped Polyenes.

Catherine P McGeough, Alexandra E Strom, Timothy F Jamison

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Synthesis of theOrganic letters · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Catherine P McGeoughDepartment of Chemistry , Massachusetts Institute of Technology , 77 Massachusetts Avenue , Cambridge , Massachusetts 02139 , United States.
Alexandra E StromDepartment of Chemistry , Massachusetts Institute of Technology , 77 Massachusetts Avenue , Cambridge , Massachusetts 02139 , United States.
Timothy F JamisonDepartment of Chemistry , Massachusetts Institute of Technology , 77 Massachusetts Avenue , Cambridge , Massachusetts 02139 , United States.ORCID 0000-0002-8601-7799

Funding

Synthetic Strategies based on expoxide coupling reactionsR01GM072566 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JAMISON, TIMOTHY F · 2005 to 2017
$3.1M
The Continuous Flow Total Synthesis of a Series of Analogs of the Cephalotaxus Esters for the Development of Novel Antileukemia TherapiesF32GM117710 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI STROM, ALEXANDRA EVE · 2016 to 2017
$101k
NIGMS NIH HHS F32 GM117710NIGMS NIH HHS R01 GM072566
6 · The paper itself

Abstract

Skipped polyenes featuring high ( E)-selectivity and varying methyl substitution patterns are synthesized using a nickel-catalyzed cross-coupling reaction between allyl trifluoroacetates and vinyl bromides. The utility of this cross-electrophile coupling is showcased in part by the synthesis of the RST fragment of the marine ladder polyether, maitotoxin. Construction of this fragment is particularly challenging due to the alternating methyl substitution pattern.

Indexed as

CatalysisMolecular StructureNickelPolyenesVinyl CompoundsNickelPolyenesvinyl bromideVinyl Compounds

Identifiers

PMID31046296
PMCPMC6681449

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.