Evidence map›Paper›PMID 31046177›Full record

ArticleAngewandte Chemie (International ed. in English)2019

Induction of a Four-Way Junction Structure in the DNA Palindromic Hexanucleotide 5'-d(CGTACG)-3' by a Mononuclear Platinum Complex.

Vincent H S van Rixel, Anja Busemann, Mathijs F Wissingh, Samantha L Hopkins, Bianka Siewert, Corjan van de Griend, Maxime A Siegler, Tiziano Marzo, Francesco Papi, Marta Ferraroni and 4 more

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Interactions of elongated dinuclear metallo-cylinders with DNA three-way and four-way junctions.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Article
  2. Article
  3. Supramolecular Recognition of a DNA Four-Way Junction by an MAngewandte Chemie (International ed. in English) · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Ruthenium-based PACT agents based on bisquinoline chelates: synthesis, photochemistry, and cytotoxicity.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2021
    Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Vincent H S van RixelLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, PO Box 9502, 2333CC, Leiden, The Netherlands.
Anja BusemannLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, PO Box 9502, 2333CC, Leiden, The Netherlands.
Mathijs F WissinghLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, PO Box 9502, 2333CC, Leiden, The Netherlands.
Samantha L HopkinsLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, PO Box 9502, 2333CC, Leiden, The Netherlands.
Bianka SiewertLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, PO Box 9502, 2333CC, Leiden, The Netherlands.
Corjan van de GriendLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, PO Box 9502, 2333CC, Leiden, The Netherlands.
Maxime A SieglerJohns Hopkins University, USA.
Tiziano MarzoDepartment of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126, Pisa, Italy.
Francesco PapiDepartment of Chemistry, University of Florence, Via della Lastruccia 3, 50019, Sesto Fiorentino (FI), Italy.
Marta FerraroniDepartment of Chemistry, University of Florence, Via della Lastruccia 3, 50019, Sesto Fiorentino (FI), Italy.
Paola GratteriDepartment NEUROFARBA-Pharmaceutical and Nutraceutical section, Laboratory of Molecular Modeling Cheminformatics and QSAR, University of Florence, Via Ugo Schiff 6, 50019, Sesto Fiorentino (FI), Italy.
Carla BazzicalupiDepartment of Chemistry, University of Florence, Via della Lastruccia 3, 50019, Sesto Fiorentino (FI), Italy.
Luigi MessoriDepartment of Chemistry "Ugo Schiff", University of Florence, Italy.
Sylvestre BonnetLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, PO Box 9502, 2333CC, Leiden, The Netherlands.ORCID 0000-0002-5810-3657

Funding

European Cooperation in Science and Technology CM1105H2020 European Research Council Starting GrantNederlandse Organisatie voor Wetenschappelijk Onderzoek VIDI grant
6 · The paper itself

Abstract

Four-way junctions (4WJs) are supramolecular DNA assemblies comprising four interacting DNA strands that in biology are involved in DNA-damage repair. In this study, a new mononuclear platinum(II) complex 1 was prepared that is capable of driving the crystallization of the DNA oligomer 5'-d(CGTACG)-3' specifically into a 4WJ-like motif. In the crystal structure of the 1-CGTACG adduct, the distorted-square-planar platinum complex binds to the core of the 4WJ-like motif through π-π stacking and hydrogen bonding, without forming any platinum-nitrogen coordination bonds. Our observations suggest that the specific molecular properties of the metal complex are crucially responsible for triggering the selective assembly of this peculiar DNA superstructure.

Indexed as

DNAHumansModels, MolecularNucleic Acid ConformationPlatinumDNAPlatinumhydrogen bondingmetallodrugsnucleic acidsplatinumsupramolecular chemistry

Identifiers

PMID31046177
PMCPMC6618160

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.