ArticleMedicine2019
Metal nickel exposure increase the risk of congenital heart defects occurrence in offspring: A case-control study in China.
Article in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Exposure to Endocrine-Disrupting Chemicals and Congenital Heart Diseases: The Pooled Results Based on the Current Evidence.Pediatric cardiology · 2025Pooled it
- Evaluation of Fetal Exposures to Metals and Metalloids through Meconium Analyses: A Review.International journal of environmental research and public health · 2021Pooled it
- Nickel exposure disrupts epigenetic repression of developmental genes in mouse embryonic stem cells.Toxicology and applied pharmacology · 2026Article
- Multiple-element exposure in early pregnancy and birth defects: a nested case-control study based on the China birth cohort study.Frontiers in nutrition · 2026Article
- Industrial air pollution and newborn hearing screening failure.Journal of hazardous materials · 2025Article
- Relationships of the serum levels of toxic trace elements in pregnant women versus exposure to second-hand smoke.Scientific reports · 2025Article
- Heavy Metal Exposure-induced Cardiovascular Diseases: Molecular Mechanisms and Therapeutic Role of Antioxidants.Current medicinal chemistry · 2025Review
- Review
- Trace Element Concentrations in Autopsied Heart Tissues from Patients with Secondary Cardiomyopathy.Biological trace element research · 2024Article
- Relationship between pregnant women's combined exposure to heavy metals and their offspring's congenital heart defects in Lanzhou, China.Frontiers in pediatrics · 2024Article
- Review
- Article
- Contaminant Metals and Cardiovascular Health.Journal of cardiovascular development and disease · 2023Review
- Mediation Effect of Body Mass Index on the Association of Urinary Nickel Exposure with Serum Lipid Profiles.Biological trace element research · 2023Article
- Exposure to essential and non-essential trace elements and risks of congenital heart defects: A narrative review.Frontiers in nutrition · 2023Review
- Carcinogenic Risk of Pb, Cd, Ni, and Cr and Critical Ecological Risk of Cd and Cu in Soil and Groundwater around the Municipal Solid Waste Open Dump in Central Thailand.Journal of environmental and public health · 2022Article
- Relationship between maternal exposure to heavy metal titanium and offspring congenital heart defects in Lanzhou, China: A nested case-control study.Frontiers in public health · 2022Article
- Pregnancy complications effect on the nickel content in maternal blood, placenta blood and umbilical cord blood during pregnancy.World journal of clinical cases · 2021Article
- Assessing reference levels of nickel and chromium in cord blood, maternal blood and placenta specimens from Ankara, TurkeyJournal of the Turkish German Gynecological Association · 2021Article
- Bioaccumulation of Toxic Metals in Children Exposed to Urban Pollution and to Cement Plant Emissions.Exposure and health · 2021Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have investigated heavy metal exposure could increase the occurrence of congenital heart defects (CHDs). However, there are limited data regarding the relationship between exposure to nickel and CHDs occurrence in offspring. The aim of this study was to analyze the association between nickel exposure in mothers and the risk of CHDs in offspring. MATERIALS AND
methodsTo explore the association of nickel exposure and occurrence of CHD, a case-control study with 490 controls and 399 cases with CHDs in China were developed. The concentrations of nickel in hair of pregnant woman and fetal placental tissue were measured and used a logistic regression analysis to explore the relationship between nickel exposure and risk of CHD.
resultsThe median concentrations of nickel were 0.629 ng/mg, P < .05 (adjusted odds ratio [aOR], 1.326; 95% CI, 1.003-1.757) and 0.178 ng/mg, P < .05 (aOR, 2.204; 95% CI, 0.783-6.206), in maternal hair and in fetal placental tissue in the CHD group, respectively. Significant differences in the level of nickel in hair were also found in the different CHD subtypes including septal defects (P < .05), conotruncal defects (P < .05), right ventricular outflow tract obstruction (P < .01), and left ventricular outflow tract obstruction (P < .05). Dramatically different nickel concentrations in fetal placenta tissue were found in cases with other heart defects (P < .05).
conclusionsThe finding suggested that the occurrence of CHDs may be associated with nickel exposure.
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