SynthesisPain2019
Quantitative sensory testing and predicting outcomes for musculoskeletal pain, disability, and negative affect: a systematic review and meta-analysis.
Synthesis in Pain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 117 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Acute Effects of a High Intensity Training Protocol on Pain Processing and Inflammatory Parameters in Persons With Chronic Nonspecific Low Back Pain.
Combination of THC and CBD as Novel Treatment for Co-Occurring Opioid Use Disorder and Chronic Pain
Who cites it
117 citing papers in PubMed, 6 syntheses or guidelines pooled it, 218 citations in OpenAlex.
- Physical and Psychological Predictors for Persistent and Recurrent Non-Specific Neck Pain: A Systematic Review.European journal of pain (London, England) · 2025Pooled it
- Thriving when living with chronic pain: A qualitative evidence synthesis of individuals' experiences.British journal of health psychology · 2025Pooled it
- An overview of systematic reviews examining the quantitative sensory testing-derived hypoalgesic effects of manual therapy for musculoskeletal pain.The Journal of manual & manipulative therapy · 2024Pooled it
- Does manual therapy meaningfully change quantitative sensory testing and patient reported outcome measures in patients with musculoskeletal impairments related to the spine?: A 'trustworthy' systematic review and meta-analysis.The Journal of manual & manipulative therapy · 2024Pooled it
- The Analgesic Effect of Transcranial Direct Current Stimulation in Fibromyalgia: A Systematic Review, Meta-Analysis, and Meta-Regression of Potential Influencers of Clinical Effect.Neuromodulation : journal of the International Neuromodulation Society · 2023Pooled it
- Psychometric properties of quantitative sensory testing in healthy and patients with shoulder pain: A systematic review.Journal of musculoskeletal & neuronal interactions · 2023Pooled it
- Trial
- Effect of manual therapy with exercise in patients with chronic cervical radiculopathy: a randomized clinical trial.Trials · 2021Trial
- Does Quantitative Sensory Testing Improve Prediction of Chronic Pain Trajectories? A Longitudinal Study of Youth With Functional Abdominal Pain Participating in a Randomized Controlled Trial of Cognitive Behavioral Treatment.The Clinical journal of pain · 2021Trial
- Altered somatosensory temporal discrimination in chronic non-specific low back pain patients with central sensitization-related features: a cross-sectional study.The Korean journal of pain · 2026Article
- Article
- Patient Experiences and Preliminary Effects of Virtual Reality Based Pain Treatment in Rheumatoid Arthritis Patients With Persistent Pain Despite Low Disease Activity: A Mixed Method Pilot Study.Musculoskeletal care · 2026Article
- Psychological Profiling and Quantitative Sensory Testing Parameters as Predictors of Experimental Induced Muscle Pain.European journal of pain (London, England) · 2026Article
- Longitudinal Changes in Somatosensory Function and Their Association with Pain Trajectory Groups in a Portuguese Cancer Center Cohort.Biomedicines · 2026Article
- Complex intervention including pain science education and patient-led goal setting-based self-management strategies for management of aromatase inhibitor-induced musculoskeletal symptoms: a single-arm feasibility and pilot study.Journal of cancer survivorship : research and practice · 2026Article
- Autonomic Dysfunction, Psychosocial Factors, and Pain Sensitivity in Persistent Spinal Pain: A Systematic Review.Journal of clinical medicine · 2026Review
- Greater endogenous pain facilitation is associated with lower spinal excitability and maximal knee extension strength deficits in athletes with patellar tendinopathy.European journal of applied physiology · 2026Article
- Observational
- Influence of psychological and somatosensory characteristics on treatment outcomes in adolescent chronic postsurgical and primary pain.Pain reports · 2026Article
- Trajectories of Pain Processing in Recurrent Acute and Chronic Pancreatitis: A Longitudinal Quantitative Sensory Testing Study.European journal of pain (London, England) · 2026Observational
57 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Hypersensitivity due to central pain mechanisms can influence recovery and lead to worse clinical outcomes, but the ability of quantitative sensory testing (QST), an index of sensitisation, to predict outcomes in chronic musculoskeletal disorders remains unclear. We systematically reviewed the evidence for ability of QST to predict pain, disability, and negative affect using searches of CENTRAL, MEDLINE, EMBASE, AMED, CINAHL, and PubMed databases up to April 2018. Title screening, data extraction, and methodological quality assessments were performed independently by 2 reviewers. Associations were reported between baseline QST and outcomes using adjusted (β) and unadjusted (r) correlations. Of the 37 eligible studies (n = 3860 participants), 32 were prospective cohort studies and 5 randomised controlled trials. Pain was an outcome in 30 studies, disability in 11, and negative affect in 3. Meta-analysis revealed that baseline QST predicted musculoskeletal pain (mean r = 0.31, 95% confidence interval [CI]: 0.23-0.38, n = 1057 participants) and disability (mean r = 0.30, 95% CI: 0.19-0.40, n = 290 participants). Baseline modalities quantifying central mechanisms such as temporal summation and conditioned pain modulation were associated with follow-up pain (temporal summation: mean r = 0.37, 95% CI: 0.17-0.54; conditioned pain modulation: mean r = 0.36, 95% CI: 0.20-0.50), whereas baseline mechanical threshold modalities were predictive of follow-up disability (mean r = 0.25, 95% CI: 0.03-0.45). Quantitative sensory testing indices of pain hypersensitivity might help develop targeted interventions aiming to improve outcomes across a range of musculoskeletal conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.